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Effects of artemisinin and its derivatives on growth inhibition and apoptosis of oral cancer cells

DC FieldValueLanguage
dc.contributor.author육종인-
dc.contributor.author차인호-
dc.contributor.author김형준-
dc.contributor.author남웅-
dc.contributor.author유주경-
dc.contributor.author김형준-
dc.date.accessioned2014-12-21T16:38:34Z-
dc.date.available2014-12-21T16:38:34Z-
dc.date.issued2007-
dc.identifier.issn1043-3074-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/96074-
dc.description.abstractBACKGROUND: Artemisinin is of special biological interest because of its outstanding antimalarial activity. Recently, it was reported that artemisinin has antitumor activity. Its derivatives, artesunate, arteether, and artemeter, also have antitumor activity against melanoma, breast, ovarian, prostate, CNS, and renal cancer cell lines. Recently, monomer, dimer, and trimer derivatives were synthesized from deoxoartemisinin, and the dimers and the trimers were found to have much more potent antitumor activity than the monomers. METHODS: We evaluated the antitumor activity of artemisinin and its various derivatives (dihydroartemisinin, dihydroartemisinin 12-benzoate, 12-(2'-hydroxyethyl) deoxoartemisinin, 12-(2'-ethylthio) deoxoartemisinin dimer, deoxoartemisinin trimer) in comparison with paclitaxel (Taxol), 5-fluorouracil (5-FU), cisplatin in vitro. RESULTS: In this study, the deoxoartemisinin trimer had the most potent antitumor effect (IC(50) = 6.0 microM), even better than paclitaxel (IC(50) = 13.1 microM), on oral cancer cell line (YD-10B). In addition, it induced apoptosis through a caspase-3-dependent mechanism. CONCLUSION: The deoxoartemisinin trimer was found to have greater antitumor effect on tumor cells than other commonly used chemotherapeutic drugs, such as 5-FU, cisplatin, and paclitaxel. Furthermore, the ability of artemisinin and its derivatives to induce apoptosis highlights their potential as chemotherapeutic agents, for many anticancer drugs achieve their antitumor effects by inducing apoptosis in tumor cells.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfHEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAntineoplastic Agents, Phytogenic/pharmacology*-
dc.subject.MESHApoptosis/drug effects*-
dc.subject.MESHArtemisia-
dc.subject.MESHArtemisinins/pharmacology*-
dc.subject.MESHCarcinoma, Squamous Cell/pathology*-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCell Proliferation/drug effects*-
dc.subject.MESHDNA Fragmentation/drug effects-
dc.subject.MESHDrug Screening Assays, Antitumor*-
dc.subject.MESHHumans-
dc.subject.MESHMouth Neoplasms/pathology*-
dc.subject.MESHSesquiterpenes/pharmacology*-
dc.subject.MESHTumor Cells, Cultured-
dc.titleEffects of artemisinin and its derivatives on growth inhibition and apoptosis of oral cancer cells-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Pathology (구강병리학)-
dc.contributor.googleauthorWoong Nam-
dc.contributor.googleauthorJungae Tak-
dc.contributor.googleauthorIn-Ho Cha-
dc.contributor.googleauthorHyung-Jun Kim-
dc.contributor.googleauthorJong-In Yook-
dc.contributor.googleauthorMankil Jung-
dc.contributor.googleauthorJu-Kyoung Ryu-
dc.identifier.doi10.1002/hed.20524-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02536-
dc.contributor.localIdA01260-
dc.contributor.localIdA02512-
dc.contributor.localIdA04002-
dc.relation.journalcodeJ00963-
dc.identifier.eissn1097-0347-
dc.identifier.pmid17163469-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/hed.20524/abstract-
dc.contributor.alternativeNameYook, Jong In-
dc.contributor.alternativeNameCha, In Ho-
dc.contributor.alternativeNameKim, Hyung Jun-
dc.contributor.alternativeNameNam, Woong-
dc.contributor.alternativeNameRyu, Ju Kyoung-
dc.contributor.affiliatedAuthorYook, Jong In-
dc.contributor.affiliatedAuthorNam, Woong-
dc.contributor.affiliatedAuthorRyu, Ju Kyoung-
dc.contributor.affiliatedAuthorCha, In Ho-
dc.rights.accessRightsnot free-
dc.citation.volume29-
dc.citation.number4-
dc.citation.startPage335-
dc.citation.endPage340-
dc.identifier.bibliographicCitationHEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.29(4) : 335-340, 2007-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers

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