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Potent HAT Inhibitory Effect of Aqueous Extract from Bellflower(platycodon grandiflorum) Roots on Androgen Receptor-mediated Transcriptional Regulation
DC Field | Value | Language |
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dc.contributor.author | 김하일 | - |
dc.contributor.author | 윤호근 | - |
dc.contributor.author | 이유현 | - |
dc.date.accessioned | 2014-12-21T16:37:22Z | - |
dc.date.available | 2014-12-21T16:37:22Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1226-7708 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96036 | - |
dc.description.abstract | Histone acetyltransferase (HAT) is a family of enzymes that regulate histone acetylation. Dysfunction of HAT plays a critical role in the development of cancer. Here we have screened the various plant extracts to find out the potent HAT inhibitors. The bellflower(platycodon grandiflorum) root have exhibited approximately 30% of the inhibitory effects on HAT activity, especially p300 and CBP (CREB-binding protein) at the concentration of 100 μg/mL. The cell viability was decreased approximately 52% in LNCaP cell for 48 hr incubation. Furthermore, mRNA level of 3 androgen receptor target genes, PSA, NKX3.1, and TSC22 were decreased with bellflower root extract treatment (100 μg/mL) in the presence of androgen. In ChIP assay, the acetylation of histone H3 and H4 in PSA promoter region was dramatically repressed by bellflower root treatment, but not TR target gene, D1. Therefore, the potent HAT inhibitory effect of bellflower root led to the decreased transcription of AR target genes and prostate cancer cell growth with the repression of histone hyperacetylation. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 457~462 | - |
dc.relation.isPartOf | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | bellflower root | - |
dc.subject.MESH | histone acetyltransferase | - |
dc.subject.MESH | androgen receptor | - |
dc.title | Potent HAT Inhibitory Effect of Aqueous Extract from Bellflower(platycodon grandiflorum) Roots on Androgen Receptor-mediated Transcriptional Regulation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biochemistry & Molecular Biology (생화학,분자생물학) | - |
dc.contributor.googleauthor | Yoo-Hyun Lee | - |
dc.contributor.googleauthor | Yong Jun Kim | - |
dc.contributor.googleauthor | Ho-Geun Yoon | - |
dc.contributor.googleauthor | Hong Yon Cho | - |
dc.contributor.googleauthor | Ha-Il Kim | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01092 | - |
dc.contributor.localId | A02625 | - |
dc.contributor.localId | A03017 | - |
dc.relation.journalcode | J00901 | - |
dc.identifier.eissn | 2092-6456 | - |
dc.identifier.url | http://www.dbpia.co.kr/Article/1606665 | - |
dc.contributor.alternativeName | Kim, Ha Il | - |
dc.contributor.alternativeName | Yoon, Ho Geun | - |
dc.contributor.alternativeName | Lee, Yoo Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Ha Il | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Geun | - |
dc.contributor.affiliatedAuthor | Lee, Yoo Hyun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 16 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 457 | - |
dc.citation.endPage | 462 | - |
dc.identifier.bibliographicCitation | FOOD SCIENCE AND BIOTECHNOLOGY, Vol.16(3) : 457-462, 2007 | - |
dc.identifier.rimsid | 35386 | - |
dc.type.rims | ART | - |
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