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Ectopic Cushing's syndrome due to concurrent corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH) secreted by malignant gastrinoma

DC Field Value Language
dc.contributor.author김똘미-
dc.contributor.author박소영-
dc.contributor.author박영년-
dc.contributor.author송시영-
dc.contributor.author윤종찬-
dc.contributor.author이시훈-
dc.contributor.author이유미-
dc.contributor.author임승길-
dc.date.accessioned2014-12-21T16:36:55Z-
dc.date.available2014-12-21T16:36:55Z-
dc.date.issued2007-
dc.identifier.issn0947-7349-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/96021-
dc.description.abstractEctopic Cushing's syndrome due to various malignancies is not uncommon. However, a few cases of ectopic Cushing's syndrome caused by corticotropin-releasing hormone (CRH), or CRH with adrenocorticotropic hormone (ACTH) have been reported. A 28-year-old woman presented with acute upper gastrointestinal bleeding caused by an active ulcer, located atypically in the 2nd portion of duodenum. Further work-up revealed high gastrin levels and abdominal computed tomography (CT) scans showed a large pancreatic head mass with multiple liver metastases. The serum cortisol and ACTH levels were checked due to hypokalemia with metabolic alkalosis and recent amenorrhea. Cortisol and ACTH were both highly elevated with pituitary hyperplasia and elevated CRH. The existence of ectopic ACTH and CRH in the liver biopsy was also demonstrated immunohistochemically. Since an operation was not feasible, chemotherapy was conducted using paclitaxel and etoposide. These two drugs were chosen according to the in vitro chemotherapy response assay to maximize the treatment. This report demonstrates concurrent ACTH- and CRH-related ectopic Cushing's syndrome caused by malignant gastrinoma with multiple liver metastases that was treated with marginal success using a multidisciplinary medical approach.-
dc.description.statementOfResponsibilityopen-
dc.format.extent13~16-
dc.relation.isPartOfEXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdrenocorticotropic Hormone/blood*-
dc.subject.MESHAdult-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols/administration & dosage-
dc.subject.MESHCorticotropin-Releasing Hormone/blood*-
dc.subject.MESHCushing Syndrome/blood*-
dc.subject.MESHCushing Syndrome/drug therapy-
dc.subject.MESHCushing Syndrome/etiology-
dc.subject.MESHCushing Syndrome/pathology-
dc.subject.MESHDuodenal Neoplasms/drug therapy-
dc.subject.MESHDuodenal Neoplasms/metabolism*-
dc.subject.MESHDuodenal Neoplasms/pathology-
dc.subject.MESHDuodenal Neoplasms/secondary-
dc.subject.MESHEtoposide/administration & dosage-
dc.subject.MESHFemale-
dc.subject.MESHGastrinoma/complications-
dc.subject.MESHGastrinoma/drug therapy-
dc.subject.MESHGastrinoma/metabolism*-
dc.subject.MESHGastrinoma/pathology-
dc.subject.MESHHumans-
dc.subject.MESHHydrocortisone/blood-
dc.subject.MESHLiver Neoplasms/drug therapy-
dc.subject.MESHLiver Neoplasms/metabolism*-
dc.subject.MESHLiver Neoplasms/pathology-
dc.subject.MESHLiver Neoplasms/secondary-
dc.subject.MESHPaclitaxel/administration & dosage-
dc.subject.MESHPancreatic Neoplasms/drug therapy-
dc.subject.MESHPancreatic Neoplasms/metabolism*-
dc.subject.MESHPancreatic Neoplasms/pathology-
dc.subject.MESHPancreatic Neoplasms/secondary-
dc.titleEctopic Cushing's syndrome due to concurrent corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH) secreted by malignant gastrinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorS. Y. Park-
dc.contributor.googleauthorY. Rhee-
dc.contributor.googleauthorS. -K. Lim-
dc.contributor.googleauthorS. Y. Song-
dc.contributor.googleauthorD. M. Kim-
dc.contributor.googleauthorS. Lee-
dc.contributor.googleauthorY. N. Park-
dc.contributor.googleauthorJ. C. Youn-
dc.identifier.doi10.1055/s-2007-948212-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00418-
dc.contributor.localIdA01563-
dc.contributor.localIdA02035-
dc.contributor.localIdA02600-
dc.contributor.localIdA02942-
dc.contributor.localIdA03012-
dc.contributor.localIdA03375-
dc.contributor.localIdA01527-
dc.relation.journalcodeJ00859-
dc.identifier.eissn1439-3646-
dc.identifier.pmid17286228-
dc.identifier.urlhttps://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-948212-
dc.contributor.alternativeNameKim, Dol Mi-
dc.contributor.alternativeNamePark, So Young-
dc.contributor.alternativeNamePark, Young Nyun-
dc.contributor.alternativeNameSong, Si Young-
dc.contributor.alternativeNameYoun, Jong Chan-
dc.contributor.alternativeNameLee, Si Hoon-
dc.contributor.alternativeNameRhee, Yumie-
dc.contributor.alternativeNameLim, Sung Kil-
dc.contributor.affiliatedAuthorKim, Dol Mi-
dc.contributor.affiliatedAuthorPark, Young Nyun-
dc.contributor.affiliatedAuthorSong, Si Young-
dc.contributor.affiliatedAuthorYoun, Jong Chan-
dc.contributor.affiliatedAuthorLee, Si Hoon-
dc.contributor.affiliatedAuthorRhee, Yumie-
dc.contributor.affiliatedAuthorLim, Sung Kil-
dc.contributor.affiliatedAuthorPark, So Young-
dc.rights.accessRightsnot free-
dc.citation.volume115-
dc.citation.number1-
dc.citation.startPage13-
dc.citation.endPage16-
dc.identifier.bibliographicCitationEXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, Vol.115(1) : 13-16, 2007-
dc.identifier.rimsid35376-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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