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Efficacy and Tolerability of the Ketogenic Diet According to Lipid:Nonlipid Ratios—Comparison of 3:1 with 4:1 Diet

DC FieldValueLanguage
dc.contributor.author강훈철-
dc.contributor.author김흥동-
dc.contributor.author서주희-
dc.contributor.author이영목-
dc.contributor.author이준수-
dc.date.accessioned2014-12-21T16:35:26Z-
dc.date.available2014-12-21T16:35:26Z-
dc.date.issued2007-
dc.identifier.issn0013-9580-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/95973-
dc.description.abstractPURPOSE: The ketogenic diet (KD) has been considered a highly potent antiepileptic treatment for intractable childhood epilepsy. In this study, we compared the antiepileptic efficacy and diet tolerability of two different diets with lipid:nonlipid ratios of 3:1 and 4:1. METHODS: Seventy-six patients with refractory childhood epilepsy were randomly placed into two groups and were started on KD diets with nonlipid:lipid ratios of either 3:1 or 4:1. Antiepileptic efficacy and diet tolerability were evaluated 3 months after initiating the diet. Patients showing seizure-free outcome with the 4:1 diet were changed to the 3:1 diet, and those without a seizure-free outcome on the 3:1 diet were changed to the 4:1 diet, for three more months, after which time their progress was monitored. RESULTS: (1) Antiepileptic efficacy was higher for the 4:1 than the 3:1 diet (p < 0.05). Twenty-two (55.0%) of 40 patients on the 4:1 diet and 11 (30.5%) of 36 patients on the 3:1 diet became seizure free. Seizure reduction of over 90% was observed in 2 (5.0%) patients on the 4:1 diet, and 2 (5.6%) on the 3:1 diet. (2) Dietary tolerability was better for the 3:1 than the 4:1 diet. Gastrointestinal symptoms were observed in 5 (13.9%) patients with the 3:1 diet and 14 (35.0%) patients with the 4:1 diet (p < 0.05). (3) For seizure-free patients who started on the 4:1 diet, antiepileptic efficacy was maintained after changing to the 3:1 diet, while 10 (83.3%) of 12 patients who were not seizure free with the 3:1 diet showed increased seizure reduction after changing to the 4:1 diet. (4) Complications from the KD and laboratory data were not significantly different between the two groups. CONCLUSIONS: The 4:1 KD showed greater antiepileptic efficacy than the 3:1 diet with higher seizure-free outcome. In most cases, seizure free outcome was maintained even after changing the ratio to 3:1. Dietary tolerability was better in the 3:1 diet than the 4:1 with less frequent gastrointestinal symptoms.-
dc.description.statementOfResponsibilityopen-
dc.format.extent801~805-
dc.relation.isPartOfEPILEPSIA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHDietary Carbohydrates/administration & dosage-
dc.subject.MESHDietary Fats/administration & dosage*-
dc.subject.MESHDietary Fats/metabolism-
dc.subject.MESHDietary Fats/therapeutic use-
dc.subject.MESHDietary Proteins/administration & dosage-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHEpilepsy/diet therapy*-
dc.subject.MESHEpilepsy/metabolism*-
dc.subject.MESHFemale-
dc.subject.MESHFood, Formulated/adverse effects-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHKetone Bodies/biosynthesis*-
dc.subject.MESHKetosis/chemically induced-
dc.subject.MESHKetosis/metabolism-
dc.subject.MESHLipids/administration & dosage*-
dc.subject.MESHLipids/therapeutic use-
dc.subject.MESHLongitudinal Studies-
dc.subject.MESHMale-
dc.subject.MESHSpasms, Infantile/diet therapy-
dc.subject.MESHSpasms, Infantile/metabolism-
dc.subject.MESHTreatment Outcome-
dc.titleEfficacy and Tolerability of the Ketogenic Diet According to Lipid:Nonlipid Ratios—Comparison of 3:1 with 4:1 Diet-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorJoo Hee Seo-
dc.contributor.googleauthorYoung Mock Lee-
dc.contributor.googleauthorHeung Dong Kim-
dc.contributor.googleauthorHoon Chul Kang-
dc.contributor.googleauthorJoon Soo Lee-
dc.identifier.doi10.1111/j.1528-1167.2007.01025.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00102-
dc.contributor.localIdA01208-
dc.contributor.localIdA01910-
dc.contributor.localIdA02955-
dc.contributor.localIdA03177-
dc.relation.journalcodeJ00793-
dc.identifier.eissn1528-1167-
dc.identifier.pmid17386059-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2007.01025.x/abstract-
dc.contributor.alternativeNameKang, Hoon Chul-
dc.contributor.alternativeNameKim, Heung Dong-
dc.contributor.alternativeNameSeo, Joo Hee-
dc.contributor.alternativeNameLee, Young Mock-
dc.contributor.alternativeNameLee, Joon Soo-
dc.contributor.affiliatedAuthorKang, Hoon Chul-
dc.contributor.affiliatedAuthorKim, Heung Dong-
dc.contributor.affiliatedAuthorSeo, Joo Hee-
dc.contributor.affiliatedAuthorLee, Young Mock-
dc.contributor.affiliatedAuthorLee, Joon Soo-
dc.rights.accessRightsnot free-
dc.citation.volume48-
dc.citation.number4-
dc.citation.startPage801-
dc.citation.endPage805-
dc.identifier.bibliographicCitationEPILEPSIA, Vol.48(4) : 801-805, 2007-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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