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Risk Factors Associated With the Onset and Progression of Posttransplantation Diabetes in Renal Allograft Recipients

DC FieldValueLanguage
dc.contributor.author강은석-
dc.contributor.author김명수-
dc.contributor.author김소헌-
dc.contributor.author김순일-
dc.contributor.author김유선-
dc.contributor.author남재현-
dc.contributor.author남정모-
dc.contributor.author안철우-
dc.contributor.author이현철-
dc.contributor.author차봉수-
dc.contributor.author허규연-
dc.date.accessioned2014-12-21T16:34:29Z-
dc.date.available2014-12-21T16:34:29Z-
dc.date.issued2007-
dc.identifier.issn0149-5992-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/95943-
dc.description.abstractOBJECTIVE: The aim of this study was to assess the incidence of posttransplantation diabetes mellitus (PTDM) in renal allograft recipients and to investigate factors contributing to the onset and progression of PTDM and its underlying pathogenic mechanism(s). RESEARCH DESIGN AND METHODS: A total of 77 patients with normal glucose tolerance (NGT) were enrolled in this study. An oral glucose tolerance test was performed 1 week before transplantation and repeated at 1 and 7 years after transplantation. RESULTS: The overall incidence of PTDM was 39% at 1 year and 35.1% at 7 years posttransplantation. The incidence for each category of PTDM was as follows: persistent PTDM (P-PTDM) (patients who developed diabetes mellitus within 1 year of transplantation and remained diabetic during 7 years), 23.4%; transient PTDM (T-PTDM) (patients who developed diabetes mellitus during the 1st year after transplantation but eventually recovered to have NGT), 15.6%; late PTDM (L-PTDM) (patients who developed diabetes mellitus later than 1 year after transplantation), 11.7%; and non-PTDM during 7 years (N-PTDM7) (patients who did not develop diabetes mellitus during 7 years), 49.3%. Older age (> or = 40 years) at transplantation was a higher risk factor for P-PTDM, whereas a high BMI (> or = 25 kg/m2) and impaired fasting glucose (IFG) at 1 year posttransplantation were higher risk factors for L-PTDM. Impaired insulin secretion rather than insulin resistance was significantly associated with the development of P- and L-PTDM. CONCLUSIONS: Impaired insulin secretion may be the main mechanism for the development of PTDM. Older age at transplantation seems to be associated with P-PTDM, whereas a high BMI and IFG at 1 year after transplantation were associated with L-PTDM.-
dc.description.statementOfResponsibilityopen-
dc.format.extent609~615-
dc.relation.isPartOfDIABETES CARE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAge Factors-
dc.subject.MESHBlood Glucose/metabolism*-
dc.subject.MESHDiabetes Mellitus/epidemiology*-
dc.subject.MESHDiabetes Mellitus/genetics-
dc.subject.MESHFemale-
dc.subject.MESHGlucose Tolerance Test-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHInsulin/metabolism*-
dc.subject.MESHInsulin Secretion-
dc.subject.MESHKidney Transplantation/adverse effects*-
dc.subject.MESHLiving Donors/statistics & numerical data-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRisk Factors-
dc.subject.MESHTime Factors-
dc.subject.MESHTransplantation, Homologous/adverse effects-
dc.titleRisk Factors Associated With the Onset and Progression of Posttransplantation Diabetes in Renal Allograft Recipients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine (예방의학)-
dc.contributor.googleauthorKyu Yeon Hur-
dc.contributor.googleauthorMyoung Soo Kim-
dc.contributor.googleauthorHyun Chul Lee-
dc.contributor.googleauthorSoon Il Kim-
dc.contributor.googleauthorBong Soo Cha-
dc.contributor.googleauthorChul Woo Ahn-
dc.contributor.googleauthorChung Mo Nam-
dc.contributor.googleauthorSo Hun Kim-
dc.contributor.googleauthorJae Hyun Nam-
dc.contributor.googleauthorEun Seok Kang-
dc.contributor.googleauthorYu Seun Kim-
dc.identifier.doi10.2337/dc06-1277-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00068-
dc.contributor.localIdA00624-
dc.contributor.localIdA00649-
dc.contributor.localIdA00785-
dc.contributor.localIdA01263-
dc.contributor.localIdA01264-
dc.contributor.localIdA02270-
dc.contributor.localIdA03301-
dc.contributor.localIdA03996-
dc.contributor.localIdA04343-
dc.contributor.localIdA00423-
dc.relation.journalcodeJ00721-
dc.identifier.eissn1935-5548-
dc.identifier.pmid17327329-
dc.identifier.urlhttp://care.diabetesjournals.org/content/30/3/609.long-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameKim, Myoung Soo-
dc.contributor.alternativeNameKim, So Hun-
dc.contributor.alternativeNameKim, Soon Il-
dc.contributor.alternativeNameKim, Yu Seun-
dc.contributor.alternativeNameNam, Jae Hyun-
dc.contributor.alternativeNameNam, Jung Mo-
dc.contributor.alternativeNameAhn, Chul Woo-
dc.contributor.alternativeNameLee, Hyun Chul-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.alternativeNameHur, Kyu Yeon-
dc.contributor.affiliatedAuthorKang, Eun Seok-
dc.contributor.affiliatedAuthorKim, So Hun-
dc.contributor.affiliatedAuthorKim, Soon Il-
dc.contributor.affiliatedAuthorKim, Yu Seun-
dc.contributor.affiliatedAuthorNam, Jae Hyun-
dc.contributor.affiliatedAuthorNam, Jung Mo-
dc.contributor.affiliatedAuthorAhn, Chul Woo-
dc.contributor.affiliatedAuthorLee, Hyun Chul-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.contributor.affiliatedAuthorHur, Kyu Yeon-
dc.contributor.affiliatedAuthorKim, Myoung Soo-
dc.rights.accessRightsnot free-
dc.citation.volume30-
dc.citation.startPage609-
dc.citation.endPage615-
dc.identifier.bibliographicCitationDIABETES CARE, Vol.30 : 609-615, 2007-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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