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Patterning the size and number of tooth and its cusps

Authors
 Jinglei Cai  ;  Sung-Won Cho  ;  Han-Sung Jung  ;  Yoon-Geun Cha  ;  Min-Jung Lee  ;  Jae-Young Kim 
Citation
 DEVELOPMENTAL BIOLOGY, Vol.304(2) : 499-507, 2007 
Journal Title
 DEVELOPMENTAL BIOLOGY 
ISSN
 0012-1606 
Issue Date
2007
MeSH
Animals ; Body Patterning ; Epithelium/embryology ; Epithelium/growth & development ; Mandible/embryology* ; Mandible/growth & development ; Mesoderm/cytology ; Mice ; Mice, Inbred ICR ; Mice, Nude ; Molar/embryology ; Molar/growth & development ; Rats ; Rats, Sprague-Dawley ; Species Specificity ; Tooth/anatomy & histology ; Tooth/embryology* ; Tooth/growth & development
Abstract
Mice and rats, two species of rodents, show some dental similarities such as tooth number and cusp number, and differences such as tooth size and cusp size. In this study, the tooth size, tooth number, cusp size and cusp number, which are four major factors of the tooth patterning, were investigated by the heterospecific recombinations of tissues from the molar tooth germs of mice and rats. Our results suggest that the dental epithelium and mesenchyme determine the cusp size and tooth size respectively and the cusp number is co-regulated by the tooth size and cusp size. It is also suggested that the mesenchymal cell number regulates not the tooth size but the tooth number. The relationships among these factors in tooth patterning including micropatterning (cusp size and cusp number) and macropatterning (tooth size and tooth number) were analyzed in a reaction diffusion mechanism. Key molecules determining the patterning of teeth remains to be elucidated for controlling the tooth size and cusp size of bioengineered tooth.
Full Text
http://www.sciencedirect.com/science/article/pii/S0012160607000164
DOI
10.1016/j.ydbio.2007.01.002
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Young(김재영)
Lee, Min Jung(이민정)
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
Cho, Sung Won(조성원) ORCID logo https://orcid.org/0000-0001-7505-9769
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95939
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