Cited 21 times in
Influence of the IL-6 −572C > G polymorphism on inflammatory markers according to cigarette smoking in Korean healthy men
DC Field | Value | Language |
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dc.contributor.author | 박성하 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 최동훈 | - |
dc.date.accessioned | 2014-12-21T16:34:10Z | - |
dc.date.available | 2014-12-21T16:34:10Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1043-4666 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95933 | - |
dc.description.abstract | We investigated whether smoking would interact with the interleukin-6 (IL-6) polymorphisms (−174G > C and −572C > G, −597G > A and −1363G > T) in determining circulating levels of inflammatory markers and its consequence to oxidative stress. The G/G genotype (n = 26) of the −572C > G in nonsmokers (n = 376) was associated with higher IL-6 (P = 0.028), fibrinogen (P = 0.007) and ox-LDL (P = 0.006) than those with C/C (n = 209) or C/G (n = 141). Results were similar for nonsmokers and smokers (n = 268), but in smokers, the −572G/G genotype was associated with a greater difference in levels of IL-6 (P = 0.031), fibrinogen (P = 0.001), ox-LDL (P = 0.037) and PGF2α (P = 0.050). IL-6 had positive relations with CRP, fibrinogen, ox-LDL and PGF2α. There was no evidence of an effect of −572C > G genotype on CRP levels in nonsmokers, however, this polymorphism was associated with a highly significant effect on CRP in smokers (P < 0.001) (genotype-smoking interaction P = 0.04, adjusted for age, BMI and IL-6). The C allele frequency at the −174 promoter region of IL-6 was very rare (<0.01) and −597G > A and −1363G > T were monomorphic in this study. Our results suggest that IL-6 −572C > G has a greater response over time to the inflammatory effects of smoking and this may result in smokers having higher oxidative stress in subjects with G/G compared to C/C or C/G. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 116~122 | - |
dc.language | CYTOKINE | - |
dc.publisher | CYTOKINE | - |
dc.relation.isPartOf | CYTOKINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Creatinine/urine | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inflammation Mediators/blood* | - |
dc.subject.MESH | Interleukin-6/blood | - |
dc.subject.MESH | Interleukin-6/genetics* | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Men | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Polymorphism, Genetic* | - |
dc.subject.MESH | Reference Values | - |
dc.subject.MESH | Smoking* | - |
dc.title | Influence of the IL-6 −572C > G polymorphism on inflammatory markers according to cigarette smoking in Korean healthy men | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.contributor.googleauthor | Dong-Jik Shin | - |
dc.contributor.googleauthor | Oh Yoen Kim | - |
dc.contributor.googleauthor | Jey Sook Chae | - |
dc.contributor.googleauthor | Soo Jeong Koh | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Kyung-Kyun Shin | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.contributor.googleauthor | Hyae Jin Kim | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.identifier.doi | 10.1016/j.cyto.2007.06.005 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A04053 | - |
dc.relation.journalcode | J00691 | - |
dc.identifier.eissn | 1096-0023 | - |
dc.identifier.pmid | 17689974 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1043466607001627 | - |
dc.subject.keyword | IL-6 −572C > G polymorphism | - |
dc.subject.keyword | Smoking | - |
dc.subject.keyword | Inflammation | - |
dc.subject.keyword | Oxidative stress | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 39 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 116 | - |
dc.citation.endPage | 122 | - |
dc.identifier.bibliographicCitation | CYTOKINE, Vol.39(2) : 116-122, 2007 | - |
dc.identifier.rimsid | 35311 | - |
dc.type.rims | ART | - |
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