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Genetic polymorphism in the pregnancy-associated plasma protein-A associated with acute myocardial infarction

DC FieldValueLanguage
dc.contributor.author고영국-
dc.contributor.author김중선-
dc.contributor.author박성하-
dc.contributor.author박찬미-
dc.contributor.author장양수-
dc.contributor.author정남식-
dc.contributor.author최동훈-
dc.contributor.author하종원-
dc.date.accessioned2014-12-21T16:33:49Z-
dc.date.available2014-12-21T16:33:49Z-
dc.date.issued2007-
dc.identifier.issn0954-6928-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/95922-
dc.description.abstractBACKGROUND: Pregnancy-associated plasma protein-A (PAPP-A) is a high-molecular-weight, zinc-binding matrix metalloproteinase that is known to be abundantly expressed in ruptured plaques. Previous studies have shown PAPP-A to be a significant marker of plaque instability and cardiovascular events in patients with acute coronary syndromes. Because the activity of PAPP-A may be modulated by genetic variants in the PAPP-A genes, we tried to determine the association of PAPP-A gene with acute myocardial infarction (AMI). METHODS: We analyzed four single nucleotide polymorphisms (SNPs) of PAPP-A gene variants and seven other polymorphisms of cytokine genes that have been reported to have functional significance (RANTES G-403A, MCP1 G-2518A, CRP A2147G, CRP G-717A, AGER G557A, LTA T26A, IL-6 G-572C) for possible association with AMI in 170 unrelated AMI patients and unrelated age-matched controls, respectively. RESULTS: The average age of the study population was 62.2+/-11.4 years in AMI patients and 62.6+/-10.4 years in healthy controls. Multiple logistic regression analysis with risk factors such as age, male sex, smoking, hypertension, diabetes mellitus, and dyslipidemia revealed the PAPP-A IVS6+95 C allele to be associated with an increased risk of AMI (dominancy: odds ratio, 2.13; 95% confidence interval, 1.12-4.07; P=0.022; codominancy: odds ratio, 1.89; 95% confidence interval, 1.14-3.16; P=0.015). CONCLUSIONS: We found, for the first time, that PAPP-A IVS6+95 C allele is an independent risk factor for AMI even after adjustment for traditional risk factors. The determination of such genotype contributing to AMI could provide a new tool for identifying high-risk individuals.-
dc.description.statementOfResponsibilityopen-
dc.format.extent417~422-
dc.relation.isPartOfCORONARY ARTERY DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleGenetic polymorphism in the pregnancy-associated plasma protein-A associated with acute myocardial infarction-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biostatistics (의학통계학)-
dc.contributor.googleauthorSungha Park-
dc.contributor.googleauthorJong-Chan Youn-
dc.contributor.googleauthorNamsik Chung-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorJong-Won Ha-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorYoung-Guk Ko-
dc.contributor.googleauthorJung-Sun Kim-
dc.contributor.googleauthorChan-Mi Park-
dc.contributor.googleauthorDong-Jik Shin-
dc.identifier.doi10.1097/MCA.0b013e328241d967-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00127-
dc.contributor.localIdA00961-
dc.contributor.localIdA01512-
dc.contributor.localIdA01708-
dc.contributor.localIdA03448-
dc.contributor.localIdA03585-
dc.contributor.localIdA04053-
dc.contributor.localIdA04257-
dc.relation.journalcodeJ00649-
dc.identifier.eissn1473-5830-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00019501-200709000-00001&LSLINK=80&D=ovft-
dc.contributor.alternativeNameKo, Young Guk-
dc.contributor.alternativeNameKim, Jung Sun-
dc.contributor.alternativeNamePark, Sung Ha-
dc.contributor.alternativeNamePark, Chan Mi-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameChung, Nam Sik-
dc.contributor.alternativeNameChoi, Dong Hoon-
dc.contributor.alternativeNameHa, Jong Won-
dc.contributor.affiliatedAuthorKo, Young Guk-
dc.contributor.affiliatedAuthorKim, Jung Sun-
dc.contributor.affiliatedAuthorPark, Sung Ha-
dc.contributor.affiliatedAuthorPark, Chan Mi-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorChung, Nam Sik-
dc.contributor.affiliatedAuthorChoi, Dong Hoon-
dc.contributor.affiliatedAuthorHa, Jong Won-
dc.rights.accessRightsnot free-
dc.citation.volume18-
dc.citation.number6-
dc.citation.startPage417-
dc.citation.endPage422-
dc.identifier.bibliographicCitationCORONARY ARTERY DISEASE, Vol.18(6) : 417-422, 2007-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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