Cited 33 times in
The RANTES -403G > A promoter polymorphism in Korean men: Association with serum RANTES concentration and coronary artery disease
DC Field | Value | Language |
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dc.contributor.author | 신현준 | - |
dc.contributor.author | 임세중 | - |
dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2014-12-21T16:33:31Z | - |
dc.date.available | 2014-12-21T16:33:31Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0143-5221 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95912 | - |
dc.description.abstract | In the present study we investigated the association of the RANTES (regulated upon activation, normal T-cell expressed and secreted) -28C>G and -403G>A promoter polymorphisms with the concentration of serum RANTES and CAD (coronary artery disease) in Korean men. We included 553 male CAD patients with (n=176) or without (n=377) Type 2 diabetes, aged 40-65 years with previous myocardial infarction ( approximately 50%) or angiographically confirmed CAD ( approximately 50%), and 416 aged-matched healthy male controls. The main outcome measures were the OR (odds ratio) of CAD risk and the serum RANTES concentration evaluated by sandwich ELISA. Although the RANTES -28C>G genotype had no significant association with CAD risk, the presence of the minor allele of the RANTES -403G>A single nucleotide polymorphism was associated with a lower risk of CAD {OR 0.70 [95% CI (confidence interval) 0.54-0.92], P=0.011} after adjusting for age, BMI (body mass index), cigarette smoking and alcohol consumption. Serum RANTES concentrations were significantly associated with the -403G>A genotype in controls (G/G: 44.7+/-3.3 ng/ml, G/A: 36.5+/-2.0 ng/ml, A/A: 28.7+/-2.5 ng/ml; P<0.001), non-diabetic CAD patients (G/G: 50.9+/-3.0 ng/ml, G/A: 42.2+/-2.6 ng/ml, A/A: 41.3+/-4.4 ng/ml; P<0.05) and diabetic CAD patients (G/G: 58.5+/-3.5 ng/ml, G/A: 49.6+/-4.1 ng/ml, A/A: 42.2+/-4.3 ng/ml; P<0.05); however, such associations were not observed in the subgroup of CAD patients taking lipid-lowering medication. Moreover, serum RANTES was positively correlated with C-reactive protein (r=0.289, P<0.001) and platelet counts (r=0.253, P<0.001). The results of the present study demonstrate that the RANTES -403A allele is associated with lower serum RANTES concentrations and consequently with reduced CAD risk. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 349~356 | - |
dc.relation.isPartOf | CLINICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | The RANTES -403G > A promoter polymorphism in Korean men: Association with serum RANTES concentration and coronary artery disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Yangsoo JANG | - |
dc.contributor.googleauthor | Jey Sook CHAE | - |
dc.contributor.googleauthor | Jong Ho LEE | - |
dc.contributor.googleauthor | Jose M. ORDOVAS | - |
dc.contributor.googleauthor | Hyun-Joon SHIN | - |
dc.contributor.googleauthor | Se-Joong RIM | - |
dc.contributor.googleauthor | Min Ji KO | - |
dc.contributor.googleauthor | Ji Young KIM | - |
dc.contributor.googleauthor | Soo Jeong KOH | - |
dc.contributor.googleauthor | Yae Jung HYUN | - |
dc.identifier.doi | 10.1042/CS20070014 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02179 | - |
dc.contributor.localId | A03372 | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J00613 | - |
dc.identifier.eissn | 1470-8736 | - |
dc.contributor.alternativeName | Shin, Hyun Joon | - |
dc.contributor.alternativeName | Rim, Se Joong | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Shin, Hyun Joon | - |
dc.contributor.affiliatedAuthor | Rim, Se Joong | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 113 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 349 | - |
dc.citation.endPage | 356 | - |
dc.identifier.bibliographicCitation | CLINICAL SCIENCE, Vol.113(8) : 349-356, 2007 | - |
dc.identifier.rimsid | 53285 | - |
dc.type.rims | ART | - |
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