Cited 15 times in
Effect of the 252A>G polymorphism of the lymphotoxin-a gene on inflammatory markers of response to cigarette smoking in Korean healthy men
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.contributor.author | 최동훈 | - |
dc.date.accessioned | 2014-12-21T16:31:46Z | - |
dc.date.available | 2014-12-21T16:31:46Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0009-8981 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95861 | - |
dc.description.abstract | BACKGROUND: The systemic inflammatory response is heightened in smokers. We examined whether the established cardiovascular risk factor, smoking status, might interact with the lymphotoxin-alpha (LTA) gene 252A>G polymorphism in determining concentrations of TNF-alpha and eventually IL-6, adiponectin and CRP downstream in the inflammatory cascade. METHODS: We measured anthropometric parameters, serum lipid profile, glucose, TNF-alpha, IL-6, CRP, adiponectin and urinary excretion of 8-epi PGF2alpha as well as a genotyping for 252A>G polymorphism of LTA in 480 healthy Korean men. RESULTS: After adjustment for age, 208 smokers with an average consumption of 18+/-1 cigarettes/d had higher concentrations of TNF-alpha, IL-6, CRP and urinary excretion of 8-epi PGF2alpha than nonsmokers (n=272). Nonsmokers with G/G had higher TNF-alpha and 8-epi PGF2alpha concentrations than those with A/A or A/G. TNF-alpha concentrations were higher in smokers than nonsmokers of the same genotype. Smokers with G/G showed higher TNF-alpha concentration than those with A/A and had higher IL-6 and urinary 8-epi PGF2alpha concentrations than those with A/G or A/A. Furthermore, smokers carrying the G allele showed lower adiponectin concentrations than those with A/A. There are main effects of genotype and smoking, as well as the smoking-genotype interaction to TNF-alpha concentration. CONCLUSION: Our results suggest that the LTA 252A>G polymorphism may modulate the inflammatory effects and oxidative stress of smoking. The detrimental effect of smoking is most clearly seen in men with G/G, suggesting a genotype-specific interaction with smoking. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 221~227 | - |
dc.relation.isPartOf | CLINICA CHIMICA ACTA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effect of the 252A>G polymorphism of the lymphotoxin-a gene on inflammatory markers of response to cigarette smoking in Korean healthy men | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Soo Jeong Koh | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.contributor.googleauthor | Jey Sook Chae | - |
dc.contributor.googleauthor | Hyae Jin Kim | - |
dc.contributor.googleauthor | Yae Jung Hyun | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.contributor.googleauthor | Byoung-Keuk Kim | - |
dc.contributor.googleauthor | Oh Yoen Kim | - |
dc.identifier.doi | 10.1016/j.cca.2006.10.002 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A04053 | - |
dc.relation.journalcode | J00543 | - |
dc.identifier.eissn | 1873-3492 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0009898106006863 | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 377 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 221 | - |
dc.citation.endPage | 227 | - |
dc.identifier.bibliographicCitation | CLINICA CHIMICA ACTA, Vol.377(1-2) : 221-227, 2007 | - |
dc.identifier.rimsid | 53251 | - |
dc.type.rims | ART | - |
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