Cited 11 times in
Effects of the early administration of heparin in patients with ST-elevation myocardial infarction treated by primary angioplasty
DC Field | Value | Language |
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dc.contributor.author | 장혁재 | - |
dc.date.accessioned | 2014-12-21T16:31:42Z | - |
dc.date.available | 2014-12-21T16:31:42Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1346-9843 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95859 | - |
dc.description.abstract | Background The effect of adjunctive heparin for primary angioplasty in patients with ST-elevation myocardial infarction (STEMI) is not well established, so the authors investigated the effect of early heparin administration in the emergency room (ER) on initial patency of the infarct-related artery (IRA) and on the clinical outcome in STEMI patients. Methods and Results One hundred and twenty consecutive patients who presented with STEMI less than 12 h from pain onset and who were eligible for primary percutaneous coronary intervention were allocated to an early heparin group (heparin administered in ER) or a late heparin group (heparin administered after angiography). In the early heparin group, unfractionated heparin (60 U/kg bolus IV, then 14 U · kg-1 · h-1 IV infusion) or enoxaparin (1 mg/kg bolus SC) were administered 144±95 min before angioplasty. No significant differences in baseline characteristics were observed between the early heparin group (n=56) and the late heparin group (n=64). However, initial Thrombolysis In Myocardial Infarction (TIMI) flow grade in the IRA was significantly different between the 2 groups (frequency of TIMI 0/1/2/3; 48/4/7/41% vs 70/8/11/11%, early vs late respectively, p=0.002). TIMI 2 or 3 flow was significantly more frequent in the early heparin group than in the late heparin group (48% vs 22%, p=0.002). However, no significant differences were noted between the 2 groups in terms of in-hospital major adverse cardiac events (7% vs 11%, p=0.472) and TIMI major bleeding (2% vs 3%, p=0.639). Conclusions In STEMI patients, early heparin therapy administered in the ER improves coronary patency, despite not reaching clinical benefit. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 862~867 | - |
dc.relation.isPartOf | CIRCULATION JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effects of the early administration of heparin in patients with ST-elevation myocardial infarction treated by primary angioplasty | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Woo-Young Chung | - |
dc.contributor.googleauthor | Mi-Jung Han | - |
dc.contributor.googleauthor | Yun- Shik Choi | - |
dc.contributor.googleauthor | Young-Bae Park | - |
dc.contributor.googleauthor | Byung-Hee Oh | - |
dc.contributor.googleauthor | Cheol-Ho Kim | - |
dc.contributor.googleauthor | Dong-Ju Choi | - |
dc.contributor.googleauthor | In-Ho Chae | - |
dc.contributor.googleauthor | Tae-Jin Youn | - |
dc.contributor.googleauthor | Hyuk-Jai Chang | - |
dc.contributor.googleauthor | Kwang-Il Kim | - |
dc.contributor.googleauthor | Young-Seok Cho | - |
dc.identifier.doi | 10.1253/circj.71.862 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03490 | - |
dc.relation.journalcode | J00534 | - |
dc.identifier.eissn | 1347-4820 | - |
dc.contributor.alternativeName | Chang, Hyuck Jae | - |
dc.contributor.affiliatedAuthor | Chang, Hyuck Jae | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 71 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 862 | - |
dc.citation.endPage | 867 | - |
dc.identifier.bibliographicCitation | CIRCULATION JOURNAL, Vol.71(6) : 862-867, 2007 | - |
dc.identifier.rimsid | 53249 | - |
dc.type.rims | ART | - |
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