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Synthesis of ultrasensitive magnetic resonance contrast agents for cancer imaging using PEG-fatty acid

Authors
 Jaemoon Yang  ;  Tong-Il Lee  ;  Seungjoo Haam  ;  Min Yong Huh  ;  Ho-Geun Yoon  ;  Jin-Suck Suh  ;  Yong Jin Song  ;  Choong-Hwan Lee  ;  Woochan Hyung  ;  Eun-Kyung Lim  ;  Jaemin Lee 
Citation
 CHEMISTRY OF MATERIALS, Vol.19 : 3870-3876, 2007 
Journal Title
 CHEMISTRY OF MATERIALS 
ISSN
 0897-4756 
Issue Date
2007
Abstract
Diagnosis of cancer in the early stages requires sensitive magnetic resonance (MR) probes to detect low concentrations of magnetic substances. In this study, ultrasensitive magnetic resonance contrast agents (UMRCAs) composed of magnetic nanocrystals and amphiphilic block copolymers were synthesized for cancer detection using polyethylene glycol and fatty acid. The chemical structures and the compositions of PEGylated magnetic nanoparticles were analyzed. UMRCAs displayed remarkable colloidal stability and high sensitivity as MR probes. Furthermore, UMRCAs exhibited low cytotoxicity and excellent cancer detection ability in an in vivo animal model
Full Text
http://pubs.acs.org/doi/abs/10.1021/cm070495s
DOI
10.1021/cm070495s
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95832
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