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Trichostatin A and 5-aza-2`-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors

Authors
 Eunjin Koh  ;  Russell Bandle  ;  Mary L. Stracke  ;  David D. Roberts  ;  Timothy Clair 
Citation
 CANCER LETTERS, Vol.250(1) : 53-62, 2007 
Journal Title
 CANCER LETTERS 
ISSN
 0304-3835 
Issue Date
2007
Abstract
The histone deacetylase inhibitor, trichostatin A (TSA), and the DNA methyltransferase inhibitor, 5-aza-2′-deoxycytidine (Aza-dC), induced epigenetic regulation of sphingosine-1-phosphate (S1P) receptors in human melanoma cells, switching S1P from motility inhibitor to stimulator. Quantitative PCR revealed increased expression of S1P1 and S1P3, associated with S1P-induced chemotaxis, and decreased expression of S1P2, associated with motility inhibition. Expression of lysophosphatidic acid (LPA) receptors was less affected. The TSA effect was reversible suggesting no mutational change, and Aza-dC treatment resulted in demethylation of a putative S1P1 promoter. S1P receptors, therefore, appear to be susceptible to epigenetic regulation, accompanied by altered cellular functionality.
Full Text
http://www.sciencedirect.com/science/article/pii/S0304383506005489
DOI
10.1016/j.canlet.2006.09.017
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Koh, Eun Jin(고은진) ORCID logo https://orcid.org/0000-0001-8967-6266
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95787
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