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Identical epidermal growth factor receptor mutations in adenocarcinomatous and squamous cell carcinomatous components of adenosquamous carcinoma of the lung

Authors
 Shin Myung Kang  ;  Hyun Ju Kang  ;  Joon Chang  ;  Sung Kyu Kim  ;  Kyung Young Chung  ;  Joo-Hang Kim  ;  Se Kyu Kim  ;  Dong Hwan Shin  ;  Hoguen Kim  ;  Ju Hye Shin 
Citation
 Cancer, Vol.109(3) : 581-587, 2007 
Journal Title
 Cancer 
ISSN
 0008-543X 
Issue Date
2007
Abstract
BACKGROUND: Adenosquamous carcinoma of the lung is composed of adenocarcinomatous and squamous cell carcinomatous components. The epidermal growth factor receptor (EGFR) mutations occur mostly in adenocarcinomas and rarely in squamous cell carcinoma of lung. Attempts to investigate the EGFR mutation status in each component of adenosquamous carcinoma and to characterize the patients according to mutation status may help to understand the histogenesis of adenosquamous carcinoma. METHODS: The mutation status of EGFR kinase domain from exon 18 to 21 was investigated in 25 Korean patients with adenosquamous carcinoma by polymerase chain reaction-single strand conformation polymorphism using the tissues of each component from the adenosquamous carcinoma tumor. Clinicopathologic characteristics of the patients according to the status of EGFR mutations were compared. RESULTS: EGFR mutations were identified in 11 (44%) patients: 9 mutations were in exon 19, 1 in exon 20, and 1 in exon 21. EGFR mutations were significantly more frequent (P = .005) in women (n = 8, 80%) than men (n = 3, 20%). Never-smokers (n = 8, 62%) had EGFR mutations more commonly than smokers (n = 3, 25%; P = .111). Identical EGFR mutations in both components of adenosquamous carcinoma were confirmed by nucleotide sequencing. CONCLUSIONS: The frequency of EGFR mutation and clinicopathologic characteristics of the EGFR mutants in adenosquamous carcinoma are similar to those of Asian patients with adenocarcinomas. Identical EGFR mutations in both components suggest the possibility of monoclonality in the histogenesis of adenosquamous carcinoma.
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T200700153.pdf Download
DOI
10.1002/cncr.22413
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
강신명(Kang, Shin Myung)
강현주(Kang, Hyun Ju)
김성규(Kim, Sung Kyu)
김세규(Kim, Se Kyu)
김주항(Kim, Joo Hang)
김호근(Kim, Ho Keun)
신동환(Shin, Dong Hwan)
장준(Chang, Joon) ORCID logo https://orcid.org/0000-0003-4542-6841
정경영(Chung, Kyung Young)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95767
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