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Anti-Histone Acetyltransferase Activity from Allspice Extracts Inhibits Androgen Receptor-Dependent Prostate Cancer CellGrowth

DC Field Value Language
dc.contributor.author윤호근-
dc.contributor.author이유현-
dc.contributor.author홍순원-
dc.contributor.author김하일-
dc.date.accessioned2014-12-21T16:27:14Z-
dc.date.available2014-12-21T16:27:14Z-
dc.date.issued2007-
dc.identifier.issn0916-8451-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/95722-
dc.description.abstractHistone acetylation depends on the activity of two enzyme families, histone acetyltransferase (HAT) and deacetylase (HDAC). In this study, we screened various plant extracts to find potent HAT inhibitors. Hot water extracts of allspice inhibited HAT activity, especially p300 and CBP (40% at 100 μg/ml). The mRNA levels of two androgen receptor (AR) regulated genes, PSA and TSC22, decreased with allspice treatment (100 μg/ml). Importantly, in IP western analysis, AR acetylation was dramatically decreased by allspice treatment. Furthermore, chromatin immunoprecipitation indicated that the acetylation of histone H3 in the PSA and B2M promoter regions was also repressed. Finally, allspice treatment reduced the growth of human prostate cancer cells, LNCaP (50% growth inhibition at 200 μg/ml). Taken together, our data indicate that the potent HAT inhibitory activity of allspice reduced AR and histone acetylation and led to decreased transcription of AR target genes, resulting in inhibition of prostate cancer cell growth.-
dc.description.statementOfResponsibilityopen-
dc.format.extent2712~2719-
dc.relation.isPartOfBIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAnti-Histone Acetyltransferase Activity from Allspice Extracts Inhibits Androgen Receptor-Dependent Prostate Cancer CellGrowth-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry & Molecular Biology (생화학,분자생물학)-
dc.contributor.googleauthorYoo-Hyun LEE-
dc.contributor.googleauthorSoon Won HONG-
dc.contributor.googleauthorHo-Geun YOON-
dc.contributor.googleauthorChang-Hoon KIM-
dc.contributor.googleauthorHa-Il KIM-
dc.contributor.googleauthorJiemin WONG-
dc.contributor.googleauthorMyung Gu JUNG-
dc.contributor.googleauthorHan-Cheon KIM-
dc.contributor.googleauthorHong Yon CHO-
dc.contributor.googleauthorWoojin JUN-
dc.identifier.doi10.1271/bbb.70306-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02625-
dc.contributor.localIdA03017-
dc.contributor.localIdA04411-
dc.contributor.localIdA01092-
dc.relation.journalcodeJ00328-
dc.identifier.eissn1347-6947-
dc.contributor.alternativeNameYoon, Ho Geun-
dc.contributor.alternativeNameLee, Yoo Hyun-
dc.contributor.alternativeNameHong, Soon Won-
dc.contributor.alternativeNameKim, Ha Il-
dc.contributor.affiliatedAuthorYoon, Ho Geun-
dc.contributor.affiliatedAuthorLee, Yoo Hyun-
dc.contributor.affiliatedAuthorHong, Soon Won-
dc.contributor.affiliatedAuthorKim, Ha Il-
dc.rights.accessRightsfree-
dc.citation.volume71-
dc.citation.number11-
dc.citation.startPage2712-
dc.citation.endPage2719-
dc.identifier.bibliographicCitationBIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Vol.71(11) : 2712-2719, 2007-
dc.identifier.rimsid51509-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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