Cited 20 times in
Design, synthesis, and discovery of stilbene derivatives based on lithospermic acid B as potent protein tyrosine phosphatase 1B inhibitors
DC Field | Value | Language |
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dc.contributor.author | 강은석 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 허규연 | - |
dc.date.accessioned | 2014-12-21T16:27:13Z | - |
dc.date.available | 2014-12-21T16:27:13Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95721 | - |
dc.description.abstract | Dihydroxy stilbene derivatives were designed based on lithospermic acid B and were prepared from 4-(chloromethyl)benzoic acid. The inhibitory activities of the novel compounds against protein tyrosine phosphatase 1B (PTP1B) were evaluated. 3,4-Dihydroxy stilbene carbonyl compounds (7, 11b, 27b) inhibited PTP1B with IC50 values comparable to molybdate, while the conjugation-extended compound (15b) showed inhibition 3-fold better than preclinical RK682. The introduction of electron withdrawing groups or amides into the second phenyl ring, or extension of the conjugation into the stilbene molecule may increase stability of the generated radicals. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 4481~4486 | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Design, synthesis, and discovery of stilbene derivatives based on lithospermic acid B as potent protein tyrosine phosphatase 1B inhibitors | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Mankil Jung | - |
dc.contributor.googleauthor | Yongnam Lee | - |
dc.contributor.googleauthor | Hyun-Chul Lee | - |
dc.contributor.googleauthor | Eun Seok Kang | - |
dc.contributor.googleauthor | Kyu Yeon Hur | - |
dc.contributor.googleauthor | Won Keun Oh | - |
dc.contributor.googleauthor | Namsoo Park | - |
dc.contributor.googleauthor | Dongeun Lee | - |
dc.contributor.googleauthor | Minjoo Sim | - |
dc.contributor.googleauthor | Jungae Tak | - |
dc.contributor.googleauthor | Eunyoung Lim | - |
dc.contributor.googleauthor | Heekyeong Kim | - |
dc.contributor.googleauthor | Hanjo Kim | - |
dc.contributor.googleauthor | Moonsoo Park | - |
dc.identifier.doi | 10.1016/j.bmcl.2007.06.016 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A04343 | - |
dc.relation.journalcode | J00326 | - |
dc.identifier.eissn | 1464-3405 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0960894X07006877 | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Hur, Kyu Yeon | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Hur, Kyu Yeon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 17 | - |
dc.citation.number | 16 | - |
dc.citation.startPage | 4481 | - |
dc.citation.endPage | 4486 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol.17(16) : 4481-4486, 2007 | - |
dc.identifier.rimsid | 51508 | - |
dc.type.rims | ART | - |
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