Cited 76 times in
Neural Responses to Facial Expressions of Disgust but not Fear are Modulated by Washing Symptoms in OCD
DC Field | Value | Language |
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dc.contributor.author | 안석균 | - |
dc.date.accessioned | 2014-12-21T16:26:45Z | - |
dc.date.available | 2014-12-21T16:26:45Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0006-3223 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95707 | - |
dc.description.abstract | BACKGROUND: Washing symptoms in Obsessive-Compulsive Disorder (OCD) are associated with increased trait sensitivity to disgust. This study explored neural systems underlying sensitivity to symptom-unrelated disgust and fear in OCD using functional neuroimaging. METHODS: Seventeen OCD subjects and 19 controls viewed facial expressions of disgust and fear (versus neutral) presented just above the level of conscious awareness in a backward masking paradigm. RESULTS: The OCD group showed greater activation than controls in the left ventrolateral prefrontal cortex, but reduced activation in the thalamus, to facial expressions of disgust. There were no between-group differences in response to fear. Further analysis using a median-split to divide OCD subjects into high and low washers suggested that the enhanced ventrolateral prefrontal cortex response was being driven by predominantly female OCD subjects with high washing symptoms. These subjects also reported higher levels of trait sensitivity to disgust. CONCLUSIONS: These findings are consistent with previous reports of increased response to symptom-relevant and generally disgusting stimuli in neural regions associated with disgust and autonomic response processing in OCD patients with prominent washing symptoms. Together, these findings point to increased sensitivity to disgust stimuli as a component of the pathophysiology of the washing/contamination symptom dimension of OCD. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1072~1080 | - |
dc.relation.isPartOf | BIOLOGICAL PSYCHIATRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Neural Responses to Facial Expressions of Disgust but not Fear are Modulated by Washing Symptoms in OCD | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학) | - |
dc.contributor.googleauthor | Natalia S. Lawrence | - |
dc.contributor.googleauthor | Suk Kyoon An | - |
dc.contributor.googleauthor | Mary L. Phillips | - |
dc.contributor.googleauthor | Anne Speckens | - |
dc.contributor.googleauthor | Florian Ruths | - |
dc.contributor.googleauthor | David Mataix-Cols | - |
dc.identifier.doi | 10.1016/j.biopsych.2006.06.033 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02227 | - |
dc.relation.journalcode | J00302 | - |
dc.identifier.eissn | 1873-2402 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006322306008638 | - |
dc.contributor.alternativeName | An, Suk Kyoon | - |
dc.contributor.affiliatedAuthor | An, Suk Kyoon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 61 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1072 | - |
dc.citation.endPage | 1080 | - |
dc.identifier.bibliographicCitation | BIOLOGICAL PSYCHIATRY, Vol.61(9) : 1072-1080, 2007 | - |
dc.identifier.rimsid | 45036 | - |
dc.type.rims | ART | - |
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