Cited 82 times in
Berberine-induced LDLR up-regulation involves JNK pathway
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2014-12-21T16:26:26Z | - |
dc.date.available | 2014-12-21T16:26:26Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95697 | - |
dc.description.abstract | Berberine, an herbal alkaloid, has been reported to have a lipid lowering effect by stabilizing hepatic LDLR mRNA in an ERK-dependent manner rather than promoting transcriptional activity. However, considering the complexity of interconnected signal pathways in biological processes, it is highly possible that there exist signal pathway(s) other than ERK pathway which contribute to the berberine-induced up-regulation of LDLR. In the present study, we examined possible involvement of other signal pathways in berberine-induced hepatic LDLR up-regulation. As evidenced by RT-PCR, berberine-induced LDLR mRNA expression was inhibited by JNK inhibitor SP600125 pretreatment. Furthermore, we demonstrate that putative c-jun binding site of LDLR promoter is important in berberine-induced LDLR transcription using luciferase assay. The result of EMSA also shows that berberine induces c-jun binding to LDLR promoter and this is decreased by SP600125 pretreatment. The present study demonstrates that berberine increases transcriptional activity of LDLR promoter and this involves JNK pathway. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 853~857 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Berberine-induced LDLR up-regulation involves JNK pathway | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Seahyoung Lee | - |
dc.contributor.googleauthor | Hyun-Joung Lim | - |
dc.contributor.googleauthor | Hyun-Young Park | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Kuy-Sook Lee | - |
dc.contributor.googleauthor | Jin-Hee Park | - |
dc.identifier.doi | 10.1016/j.bbrc.2007.08.060 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X07017652 | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 362 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 853 | - |
dc.citation.endPage | 857 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.362(4) : 853-857, 2007 | - |
dc.identifier.rimsid | 45031 | - |
dc.type.rims | ART | - |
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