Cited 46 times in
Molecular cloning and functional analysis of a novel oncogene, cancer-upregulated gene 2 (CUG2)
DC Field | Value | Language |
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dc.contributor.author | 송시영 | - |
dc.date.accessioned | 2014-12-21T16:26:24Z | - |
dc.date.available | 2014-12-21T16:26:24Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95696 | - |
dc.description.abstract | We examined genome-wide differences in gene expression between tumor biopsies and normal tissues in order to identify differentially regulated genes in tumors. Cancer-upregulated gene 2 (CUG2) was identified as an expressed sequence tag (EST) that exhibits significant differential expression in multiple human cancer types. CUG2 showed weak sequence homology with the down-regulator of transcription 1 (DR1) gene, a human transcription repressor. We found that EGFP-CUG2 fusion proteins were predominantly localized in the nucleus, suggesting their putative role in gene regulation. In addition, CUG2-overexpressing mouse fibroblast cells exhibited distinct cancer-specific phenotypes in vitro and developed into tumors in nude mice. Taken together, these findings suggest that CUG2 is a novel tumor-associated gene that is commonly activated in various human cancers and exhibits high transforming activities; it possibly belongs to a transcription regulator family that is involved in tumor biogenesis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 633~639 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Molecular cloning and functional analysis of a novel oncogene, cancer-upregulated gene 2 (CUG2) | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Soojin Lee | - |
dc.contributor.googleauthor | Jingu Gang | - |
dc.contributor.googleauthor | Sang Seok Koh | - |
dc.contributor.googleauthor | Si Young Song | - |
dc.contributor.googleauthor | Jinyoung Jung | - |
dc.contributor.googleauthor | Yang Soon Lee | - |
dc.contributor.googleauthor | Young-Gun Kim | - |
dc.contributor.googleauthor | Bogman Lee | - |
dc.contributor.googleauthor | Seung Ho Choo | - |
dc.contributor.googleauthor | Sun Bok Jeon | - |
dc.identifier.doi | 10.1016/j.bbrc.2007.06.102 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02035 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X07013459 | - |
dc.contributor.alternativeName | Song, Si Young | - |
dc.contributor.affiliatedAuthor | Song, Si Young | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 360 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 633 | - |
dc.citation.endPage | 639 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.360(3) : 633-639, 2007 | - |
dc.identifier.rimsid | 45030 | - |
dc.type.rims | ART | - |
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