Cited 18 times in
Developmental stage- and DNA damage-specific functions of C. elegans FANCD2
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정기양 | - |
dc.date.accessioned | 2014-12-21T16:26:03Z | - |
dc.date.available | 2014-12-21T16:26:03Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95685 | - |
dc.description.abstract | In this study, we set out to investigate the role of Fanconi anemia complementation group D2 protein (FANCD2) in developmental stage-specific DNA damage responses in Caenorhabditis elegans. A mutant C. elegans strain containing a deletion in the gene encoding the FANCD2 homolog, FCD-2, exhibited egg-laying defects, precocious oogenesis, and partial defects in fertilization. The mutant strain also had a lower hatching rate than the wild-type after γ-irradiation of embryos, but not after the irradiation of pachytene stage germ cells. This mutation sensitized pachytene stage germ cells to the genotoxic effects of photoactivated psoralen, as seen by a greatly reduced hatching rate and increased chromosomal aberrations. This mutation also enhanced physiological M-phase arrest and apoptosis. Taken together, our data reveal that the C. elegans FANCD2 homolog participates in the repair of spontaneous DNA damage and DNA crosslinks, not only in proliferating cells but also in pachytene stage cells, and it may have an additional role in double-stranded DNA break repair during embryogenesis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 479~485 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Developmental stage- and DNA damage-specific functions of C. elegans FANCD2 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | Kyong Yun Lee | - |
dc.contributor.googleauthor | Insil Yang | - |
dc.contributor.googleauthor | Hyeon-Sook Koo | - |
dc.contributor.googleauthor | Kee Yang Chung | - |
dc.contributor.googleauthor | Ok-Ryun Baek | - |
dc.contributor.googleauthor | Jung-Eun Park | - |
dc.identifier.doi | 10.1016/j.bbrc.2006.11.039 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03582 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X06025095 | - |
dc.contributor.alternativeName | Chung, Kee Yang | - |
dc.contributor.affiliatedAuthor | Chung, Kee Yang | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 352 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 479 | - |
dc.citation.endPage | 485 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.352(2) : 479-485, 2007 | - |
dc.identifier.rimsid | 45020 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.