Cited 82 times in
Atomoxetine versus Methylphenidate in Paediatric Outpatients with Attention Deficit Hyperactivity Disorder: A Randomized, Double-Blind Comparison Trial
DC Field | Value | Language |
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dc.contributor.author | 송동호 | - |
dc.contributor.author | 신의진 | - |
dc.date.accessioned | 2014-12-21T16:25:57Z | - |
dc.date.available | 2014-12-21T16:25:57Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0004-8674 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95682 | - |
dc.description.abstract | Objective: To (i) test whether atomoxetine is non-inferior to methylphenidate in treating symptoms of attention deficit hyperactivity disorder (ADHD) in paediatric patients; and (ii) determine the tolerability of the two drugs. Method: This double-blind study was conducted in 6- to 16-year-old outpatients with ADHD (DSM-IV) in China, Korea and Mexico (January–October 2004). Patients were randomly assigned to once-daily atomoxetine (0.8–1.8 mg kg−1 day−1; n = 164) or twice-daily methylphenidate (0.2–0.6 mg kg−1 day−1; n = 166) for ∼8 weeks. Primary efficacy assessment was the comparison of response rates (≥40% reduction from baseline to end point in total score) on the Attention Deficit Hyperactivity Disorder Rating Scale-IV-Parent Version: Investigator-Administered and -Scored. Tolerability measures included, but were not limited to, the assessment of treatment-emergent adverse events (TEAEs) and weight. Results: Atomoxetine was non-inferior to methylphenidate in improving ADHD symptoms based on response rates (atomoxetine, 77.4%; methylphenidate, 81.5%; one-sided 95% lower confidence limit = −11.7%, p = 0.404). Treatment-emergent adverse effects experienced significantly more frequently in the atomoxetine group, compared with the methylphenidate group, included anorexia (37.2% vs. 25.3%; p = 0.024), nausea (20.1% vs. 10.2%; p = 0.014), somnolence (26.2% vs. 3.6%; p <0.001), dizziness (15.2% vs. 7.2%; p = 0.024) and vomiting (11.6% vs. 3.6%; p = 0.007), most of which were of mild or moderate severity. Atomoxetine-treated patients experienced a small but significantly greater mean weight loss from baseline to end point than methylphenidate-treated patients (−1.2 kg vs. −0.4 kg; p <0.001). Conclusions: This study suggests that atomoxetine is non-inferior to methylphenidate in the improvement of ADHD symptoms in paediatric outpatients. Although both of the drugs were well tolerated, atomoxetine was associated with a higher incidence of TEAEs than methylphenidate. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 220~230 | - |
dc.relation.isPartOf | AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Atomoxetine versus Methylphenidate in Paediatric Outpatients with Attention Deficit Hyperactivity Disorder: A Randomized, Double-Blind Comparison Trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학) | - |
dc.contributor.googleauthor | Yufeng Wang | - |
dc.contributor.googleauthor | Yi Zheng | - |
dc.contributor.googleauthor | Louise R. Levine | - |
dc.contributor.googleauthor | David W. Williams | - |
dc.contributor.googleauthor | Haitao Gao | - |
dc.contributor.googleauthor | Maria E. Marquez-Caraveo | - |
dc.contributor.googleauthor | Dong H. Ahn | - |
dc.contributor.googleauthor | Bung N. Kim | - |
dc.contributor.googleauthor | Soo C. Cho | - |
dc.contributor.googleauthor | Yee-Jin Shin | - |
dc.contributor.googleauthor | Dong H. Song | - |
dc.contributor.googleauthor | Yasong Du | - |
dc.identifier.doi | 10.1080/00048670601057767 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02018 | - |
dc.contributor.localId | A02136 | - |
dc.relation.journalcode | J00264 | - |
dc.identifier.eissn | 1440-1614 | - |
dc.identifier.url | http://anp.sagepub.com/content/41/3/222.long | - |
dc.contributor.alternativeName | Song, Dong Ho | - |
dc.contributor.alternativeName | Shin, Yee Jin | - |
dc.contributor.affiliatedAuthor | Song, Dong Ho | - |
dc.contributor.affiliatedAuthor | Shin, Yee Jin | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 41 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 220 | - |
dc.citation.endPage | 230 | - |
dc.identifier.bibliographicCitation | AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, Vol.41(3) : 220-230, 2007 | - |
dc.identifier.rimsid | 45017 | - |
dc.type.rims | ART | - |
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