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Pharmacokinetics of GST-TatdMt, a recombinant fusion protein possessing potent anti-obesity activity, in Mice
DC Field | Value | Language |
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dc.contributor.author | 허만욱 | - |
dc.date.accessioned | 2014-12-21T16:25:15Z | - |
dc.date.available | 2014-12-21T16:25:15Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95660 | - |
dc.description.abstract | This study examined the absorption and pharmacokinetic disposition of125l-GST-TatdMt, a recombinant Tat protein possessing potent anti-obesity activity, in mice after vascular and extravascular administration. GST-TatdMt was over-expressed in E. coli, purified, and radio-iodinated using the IODO-GEN method.125I-GST-TatdMt was administered to mice by i.v., i.p. and oral administration at doses of 652.7 nCi (102.3 μg). Upon i.v. injection, the average terminal elimination half-life (t1/2,λz), AUC and AUMC were 6.4 h, 318.2 nCi·h/mL and 2518 nCi·h2/ mL, respectively. The highest radioactivity was observed in lung followed by liver, spleen, heart and kidney. The t1/2,λz values obtained from i.v., i.p., and oral administration were comparable from each other (range 5.8–6.4 h). The absolute bioavailability of125I-GST-TatdMt was 42.8% and 60.5% after p.o. and i.p. administration, respectively. Given the cell-penetrating nature,125l-GST-TatdMt may be absorbed into the systemic circulation to a relatively high extent after extravascular administration. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1162~1167 | - |
dc.relation.isPartOf | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Pharmacokinetics of GST-TatdMt, a recombinant fusion protein possessing potent anti-obesity activity, in Mice | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biochemistry & Molecular Biology (생화학,분자생물학) | - |
dc.contributor.googleauthor | Beom Soo Shin | - |
dc.contributor.googleauthor | Jin Hyuk Seo | - |
dc.contributor.googleauthor | Sun Dong Yoo | - |
dc.contributor.googleauthor | Min-Nyung Lee | - |
dc.contributor.googleauthor | Man-Wook Hur | - |
dc.identifier.doi | 10.1007/BF02980253 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04350 | - |
dc.relation.journalcode | J00229 | - |
dc.identifier.url | http://link.springer.com/article/10.1007/BF02980253 | - |
dc.contributor.alternativeName | Hur, Man Wook | - |
dc.contributor.affiliatedAuthor | Hur, Man Wook | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 30 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1162 | - |
dc.citation.endPage | 1167 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, Vol.30(9) : 1162-1167, 2007 | - |
dc.identifier.rimsid | 44999 | - |
dc.type.rims | ART | - |
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