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Questionable role of human herpesviruses in the pathogenesis of Kikuchi disease
DC Field | Value | Language |
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dc.contributor.author | 양우익 | - |
dc.date.accessioned | 2014-12-21T16:25:09Z | - |
dc.date.available | 2014-12-21T16:25:09Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0003-9985 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95657 | - |
dc.description.abstract | CONTEXT: Kikuchi disease is a self-limiting febrile lymphadenopathy characterized by a patchy area of apoptosis. Kikuchi disease is thought to be caused by a virus, but this has not been clearly demonstrated. Human herpesviruses 6 and 7 (HHV-6 and HHV-7) are lymphotropic viruses that can induce apoptosis in infected lymphocytes. Recently, HHV-8 was reported to be a possible etiologic agent of Kikuchi disease. OBJECTIVE: To investigate the incidence of HHV-6, HHV-7, and HHV-8 infection in patients with Kikuchi disease. DESIGN: Seventy archival tissue specimens (from 50 Kikuchi disease cases and 20 control cases) were tested for the presence of HHV-6 and HHV-7 using a nested polymerase chain reaction, and for the presence of HHV-8 using single-step polymerase chain reaction. Immunohistochemistry for HHV-8 expression was carried out in those cases in which HHV-8 was detected using polymerase chain reaction. RESULTS: Of the 50 cases with Kikuchi disease, 21 (42%) were HHV-6 positive and 32 (64%) were HHV-7 positive. Eight (40%) of the 20 control cases were HHV-6 positive and 9 (45%) were HHV-7 positive. Both HHV-6 and HHV-7 were detected in 15 (30%) of the cases with Kikuchi disease and in 3 (15%) of the control cases. Three (6%) of the 50 cases of Kikuchi disease were HHV-8 positive but revealed no positive cells on immunohistochemical analysis for HHV-8. Human herpesvirus 8 was not expressed in any of the control cases. CONCLUSIONS: There was no association between the presence of HHV-6 or HHV-7 and Kikuchi disease. Because the HHV-8 genome but not protein was detected in a small proportion of the cases of Kikuchi disease, its potential causative role in this disease should be determined by further studies. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 604~609 | - |
dc.relation.isPartOf | ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Questionable role of human herpesviruses in the pathogenesis of Kikuchi disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Min-Sun Cho | - |
dc.contributor.googleauthor | Hee Jung Choi | - |
dc.contributor.googleauthor | Woo Ick Yang | - |
dc.contributor.googleauthor | Woon Sup Han | - |
dc.contributor.googleauthor | Sung Eun Cho | - |
dc.contributor.googleauthor | Hae Kyung Park | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02300 | - |
dc.relation.journalcode | J00228 | - |
dc.identifier.eissn | 1543-2165 | - |
dc.identifier.url | http://www.archivesofpathology.org/doi/full/10.1043/1543-2165(2007)131[604:QROHHI]2.0.CO;2 | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | Yang, Woo Ick | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 131 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 604 | - |
dc.citation.endPage | 609 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, Vol.131(4) : 604-609, 2007 | - |
dc.identifier.rimsid | 44997 | - |
dc.type.rims | ART | - |
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