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Early postoperative intraperitoneal chemotherapy following cytoreductive surgery in patients with very advanced gastric cancer

DC Field Value Language
dc.contributor.author노성훈-
dc.contributor.author송창수-
dc.contributor.author정재호-
dc.contributor.author최승호-
dc.contributor.author형우진-
dc.date.accessioned2014-12-21T16:24:02Z-
dc.date.available2014-12-21T16:24:02Z-
dc.date.issued2007-
dc.identifier.issn1068-9265-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/95621-
dc.description.abstractBACKGROUND: The survival of patients with stage IV gastric cancer is poor due to frequent peritoneal failure. The aim of this study was to investigate the impact of early postoperative intraperitoneal chemotherapy (EPIC) after cytoreductive surgery on the long-term survival of these patients, as determined by residual disease status. METHODS: A total of 154 patients with stage IV gastric cancer were enrolled in our study. All patients underwent potentially curative or palliative resections. After surgery, the residual disease states of the patients were recorded. All patients received EPIC. RESULTS: Of all 154 patients, R0 resection was achieved in 37, R1 in 56, and R2 in 61. All patients received a mean of 4.3 EPIC perfusions. After a mean followup period of 29 months, 14 patients remained alive. The median survival of all 154 patients was 11.4 months. Survival times were analyzed according to the type of residual tumor; the median survival time was 25.5 months in the R0 group, 15.6 months in the R1 group, and 7.2 months in the R2 group (p < .001). Upon multivariate analysis, the residual tumor states and the cycle of EPIC perfusion were found to be independent prognostic predictors (p < .001 and p = .018, respectively). CONCLUSIONS: The residual tumor status is the most important predictor for the survival of very advanced gastric cancer patients who received cytoreductive surgery and EPIC. Therefore, complete cytoreductive surgery yielding R0 resection is mandatory for achieving the beneficial effects of EPIC.-
dc.description.statementOfResponsibilityopen-
dc.format.extent61~68-
dc.relation.isPartOfANNALS OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEarly postoperative intraperitoneal chemotherapy following cytoreductive surgery in patients with very advanced gastric cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorJae-Ho Cheong-
dc.contributor.googleauthorJia Yun Shen-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorSeung Ho Choi-
dc.contributor.googleauthorJian Guo Shen-
dc.contributor.googleauthorWoo Jin Hyung-
dc.contributor.googleauthorChang Soo Song-
dc.identifier.doi10.1245/s10434-006-9205-7-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04102-
dc.contributor.localIdA01281-
dc.contributor.localIdA02070-
dc.contributor.localIdA03717-
dc.contributor.localIdA04382-
dc.relation.journalcodeJ00179-
dc.identifier.eissn1534-4681-
dc.identifier.urlhttp://link.springer.com/article/10.1245%2Fs10434-006-9205-7-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameSong, Chang Soo-
dc.contributor.alternativeNameCheong, Jae Ho-
dc.contributor.alternativeNameChoi, Seung Ho-
dc.contributor.alternativeNameHyung, Woo Jin-
dc.contributor.affiliatedAuthorChoi, Seung Ho-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorSong, Chang Soo-
dc.contributor.affiliatedAuthorCheong, Jae Ho-
dc.contributor.affiliatedAuthorHyung, Woo Jin-
dc.rights.accessRightsnot free-
dc.citation.volume14-
dc.citation.number1-
dc.citation.startPage61-
dc.citation.endPage68-
dc.identifier.bibliographicCitationANNALS OF SURGICAL ONCOLOGY, Vol.14(1) : 61-68, 2007-
dc.identifier.rimsid44972-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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