Cited 108 times in
Noble Gases Without Anesthetic properties Protect Myocardium Against Intarction by Activating prosurvivalsignalingkinases and inhibiting mitochondrial permeability transition in vivo
DC Field | Value | Language |
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dc.contributor.author | 심연희 | - |
dc.date.accessioned | 2014-12-21T16:23:01Z | - |
dc.date.available | 2014-12-21T16:23:01Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0003-2999 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95589 | - |
dc.description.abstract | BACKGROUND: The anesthetic noble gas, xenon, produces cardioprotection. We hypothesized that other noble gases without anesthetic properties [helium (He), neon (Ne), argon (Ar)] also produce cardioprotection, and further hypothesized that this beneficial effect is mediated by activation of prosurvival signaling kinases [including phosphatidylinositol-3-kinase, extracellular signal-regulated kinase, and 70-kDa ribosomal protein s6 kinase] and inhibition of mitochondrial permeability transition pore (mPTP) opening in vivo. METHODS: Rabbits (n = 98) instrumented for hemodynamic measurement and subjected to a 30-min left anterior descending coronary artery (LAD) occlusion and 3 h reperfusion received 0.9% saline (control), three cycles of 70% He-, Ne-, or Ar-30% O2 administered for 5 min interspersed with 5 min of 70% N2-30% O2 before LAD occlusion, or three cycles of brief (5 min) ischemia interspersed with 5 min reperfusion before prolonged LAD occlusion and reperfusion (ischemic preconditioning). Additional groups of rabbits received selective inhibitors of phosphatidylinositol-3-kinase (wortmannin; 0.6 mg/kg), extracellular signal-regulated kinase (PD 098059; 2 mg/kg), or 70-kDa ribosomal protein s6 kinase (rapamycin; 0.25 mg/kg) or mPTP opener atractyloside (5 mg/kg) in the absence or presence of He pretreatment. RESULTS: He, Ne, Ar, and ischemic preconditioning significantly (P < 0.05) reduced myocardial infarct size [23% +/- 4%, 20% +/- 3%, 22% +/- 2%, 17% +/- 3% of the left ventricular area at risk (mean +/- sd); triphenyltetrazolium chloride staining] versus control (45% +/- 5%). Wortmannin, PD 098059, rapamycin, and atractyloside alone did not affect infarct size, but these drugs abolished He-induced cardioprotection. CONCLUSIONS: The results indicate that noble gases without anesthetic properties produce cardioprotection by activating prosurvival signaling kinases and inhibiting mPTP opening in rabbits. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 562~569 | - |
dc.relation.isPartOf | ANESTHESIA AND ANALGESIA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Noble Gases Without Anesthetic properties Protect Myocardium Against Intarction by Activating prosurvivalsignalingkinases and inhibiting mitochondrial permeability transition in vivo | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Paul S. Pagel | - |
dc.contributor.googleauthor | John G. Krolikowski | - |
dc.contributor.googleauthor | Phillip F. Pratt, Jr. | - |
dc.contributor.googleauthor | David C. Warltier | - |
dc.contributor.googleauthor | Dorothee Weihrauch | - |
dc.contributor.googleauthor | Judy R. Kersten | - |
dc.contributor.googleauthor | Suneetha Venkatapuram | - |
dc.contributor.googleauthor | Yon Hee Shim | - |
dc.identifier.doi | 10.1213/01.ane.0000278083.31991.36 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02196 | - |
dc.relation.journalcode | J00144 | - |
dc.identifier.eissn | 1526-7598 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00000539-200709000-00002&LSLINK=80&D=ovft | - |
dc.contributor.alternativeName | Shim, Yon Hee | - |
dc.contributor.affiliatedAuthor | Shim, Yon Hee | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 105 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 562 | - |
dc.citation.endPage | 569 | - |
dc.identifier.bibliographicCitation | ANESTHESIA AND ANALGESIA, Vol.105(3) : 562-569, 2007 | - |
dc.identifier.rimsid | 44952 | - |
dc.type.rims | ART | - |
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