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Antiadhesive effect of the mixed solution of sodium hyaluronate and sodium carboxymethylcellulose after endoscopic sinus surgery

Authors
 Jeong Hong Kim  ;  Joo-Hwan Lee  ;  Kyung-Su Kim  ;  Jung Ho Bae  ;  Jung Hyun Chang  ;  Joo-Heon Yoon 
Citation
 AMERICAN JOURNAL OF RHINOLOGY , Vol.21(1) : 95-99, 2007 
Journal Title
AMERICAN JOURNAL OF RHINOLOGY
ISSN
 1050-6586 
Issue Date
2007
Abstract
Background: We evaluated the clinical efficacy and safety of the mixed solution of sodium hyaluronate and sodium carboxymethylcellulose (HA-CMC) for prevention of adhesion after endoscopic sinus surgery.

Methods: Preoperative computed tomography (CT) scans were graded. At the completion of surgery, HA-CMC was applied to Merocel and repeatedly applied after the removal of Merocel. As a control, normal saline was applied. Endoscopic examination was performed postoperatively and grading was done.

Results: The rate of adhesion was the highest at 2 weeks postoperatively and was significantly lower in the HA-CMC–treated group than the control on all postoperative days. The grouping of cases by CT scores at 2 weeks postoperatively showed lower adhesion formation with the HA-CMC treatment than the control. The safety profile of the patients was normal at 4 weeks postoperatively.

Conclusion: HA-CMC is an efficacious and safe material in decreasing the incidence of adhesion after endoscopic sinus surgery.
Full Text
http://dx.doi.org/10.2500/ajr.2007.21.2911
DOI
10.2500/ajr.2007.21.2911
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Su(김경수) ORCID logo https://orcid.org/0000-0003-1460-0640
Kim, Jeong Hong(김정홍)
Bae, Jung Ho(배정호)
Yoon, Joo Heon(윤주헌)
Chang, Jung Hyun(장정현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95564
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