Cited 47 times in
Expression and localization of surfactant proteins in human nasal epithelium
DC Field | Value | Language |
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dc.contributor.author | 김창훈 | - |
dc.contributor.author | 윤주헌 | - |
dc.contributor.author | 이정권 | - |
dc.contributor.author | 이창훈 | - |
dc.date.accessioned | 2014-12-21T16:22:10Z | - |
dc.date.available | 2014-12-21T16:22:10Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1040-0605 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95562 | - |
dc.description.abstract | Surfactant proteins (SPs), designated SP-A, SP-B, SP-C, and SP-D, play an important role in surfactant metabolism and host defense mechanisms in the lung. This study investigates expression of the different SP types in human nasal mucosa and cultured normal human nasal epithelial (NHNE) cells and whether the expression of SP mRNA is influenced by the degree of mucociliary differentiation. RT-PCR was performed with mRNA from cultured NHNE cells and nasal mucosa. Immunohistochemical staining for SPs was performed on nasal mucosa specimens. Western blot analysis was performed on cell lysates from cultured NHNE cells. SP-A2, SP-B, and SP-D mRNAs were expressed in normal NHNE cells and human nasal mucosa. SPs were localized in ciliated cells of the surface epithelium and serous acini of the submucosal glands. SP-A, SP-B, and SP-D proteins were expressed in cultured NHNE cells. The degree of mucociliary differentiation influenced expression of the SP gene. We demonstrate that SP-A, SP-B, and SP-D are expressed in human nasal mucosa and cultured NHNE cells. Further study of the functional role of SPs in the upper airway is required. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | L879~L884 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Expression and localization of surfactant proteins in human nasal epithelium | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학) | - |
dc.contributor.googleauthor | Jin Kook Kim | - |
dc.contributor.googleauthor | Sung-Shik Kim | - |
dc.contributor.googleauthor | Joo-Heon Yoon | - |
dc.contributor.googleauthor | Jeung-Gweon Lee | - |
dc.contributor.googleauthor | Chang-Hoon Lee | - |
dc.contributor.googleauthor | Jae Hoon Cho | - |
dc.contributor.googleauthor | Chang-Hoon Kim | - |
dc.contributor.googleauthor | Keung Won Rha | - |
dc.identifier.doi | 10.1152/ajplung.00156.2006 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01050 | - |
dc.contributor.localId | A02604 | - |
dc.contributor.localId | A03095 | - |
dc.contributor.localId | A03250 | - |
dc.relation.journalcode | J00106 | - |
dc.identifier.eissn | 1522-1504 | - |
dc.contributor.alternativeName | Kim, Chang Hoon | - |
dc.contributor.alternativeName | Yoon, Joo Heon | - |
dc.contributor.alternativeName | Lee, Jeung Gweon | - |
dc.contributor.alternativeName | Lee, Chang Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Chang Hoon | - |
dc.contributor.affiliatedAuthor | Yoon, Joo Heon | - |
dc.contributor.affiliatedAuthor | Lee, Jeung Gweon | - |
dc.contributor.affiliatedAuthor | Lee, Chang Hoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 292 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 879 | - |
dc.citation.endPage | 884 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol.292(4) : 879-884, 2007 | - |
dc.identifier.rimsid | 43334 | - |
dc.type.rims | ART | - |
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