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Exploring molecular links between lymph node invasion and cancer prognosis in human breast cancer

 Sangwoo Kim  ;  Hojung Nam  ;  Doheon Lee 
 BMC SYSTEMS BIOLOGY, Vol.5(Suppl 2) : 4, 2011 
Journal Title
Issue Date
Breast Neoplasms/diagnosis* Breast Neoplasms/genetics Breast Neoplasms/pathology* Databases, Genetic Female Gene Expression Profiling Gene Expression Regulation, Neoplastic* Humans Lymph Nodes/pathology* Breast Neoplasms/diagnosis* ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology* ; Databases, Genetic ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic* ; Humans ; Lymph Nodes/pathology* ; Lymphatic Metastasis/pathology ; Prognosis ; Regression Analysis
Cancer Prognosis ; Class Comparison ; Stage Progression ; ONCOMINE Database ; Specific Stage Transition
BACKGROUND: Lymph node invasion is one of the most powerful clinical factors in cancer prognosis. However, molecular level signatures of their correlation are remaining poorly understood. Here, we propose a new approach, monotonically expressed gene analysis (MEGA), to correlate transcriptional patterns of lymph node invasion related genes with clinical outcome of breast cancer patients.
RESULTS: Using MEGA, we scored all genes with their transcriptional patterns over progression levels of lymph node invasion from 278 non-metastatic breast cancer samples. Applied on 65 independent test data, our gene sets of top 20 scores (positive and negative correlations) showed significant associations with prognostic measures such as cancer metastasis, relapse and survival. Our method showed better accuracy than conventional two class comparison methods. We could also find that expression patterns of some genes are strongly associated with stage transition of pathological T and N at specific time. Additionally, some pathways including T-cell immune response and wound healing serum response are expected to be related with cancer progression from pathway enrichment and common motif binding site analyses of the inferred gene sets.
CONCLUSIONS: By applying MEGA, we can find possible molecular links between lymph node invasion and cancer prognosis in human breast cancer, supported by evidences of feasible gene expression patterns and significant results of meta-analysis tests.
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1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Kim, Sangwoo(김상우) ORCID logo https://orcid.org/0000-0001-5356-0827
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