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Reproductive and Hormonal Factors Associated with Fatty or Dense Breast Patterns among Korean Women

Authors
 Jei-Hun Jeon  ;  Jung-Hyun Kang  ;  Yeonju Kim  ;  Hoo-Yeon Lee  ;  Kui Son Choi  ;  Jae Kwan Jun  ;  Dong-Kwan Oh  ;  Chang Yoon Lee  ;  Kyungran Ko  ;  Eun-Cheol Park 
Citation
 CANCER RESEARCH AND TREATMENT, Vol.43(1) : 42-48, 2011 
Journal Title
 CANCER RESEARCH AND TREATMENT 
ISSN
 1598-2998 
Issue Date
2011
Keywords
Breast ; Cross-sectional study ; Korea ; Mammography ; Risk factors
Abstract
PURPOSE: Dense breasts have been suggested as a risk factor for breast cancer, but controversy still remains. This study evaluates the association of reproductive and hormonal factors with dense breasts among Korean women. MATERIALS AND METHODS: Using a cross-sectional design, 516 women were recruited and classified for breast density patterns as being either fatty or dense, using the Breast Imaging Reporting and Data System (BI-RADS) of the American College of Radiology. Univariate and multivariate logistic regression models were used for statistical analysis. RESULTS: In univariate logistic regression, older age, higher body mass index, older age at menarche, and oral contraceptive use were associated with more fatty breasts. On the contrary, longer duration of education, alcohol consumption, lower parity, menopause and use of hormone replacement therapy were associated with dense breasts. After adjustment, age and body mass index were inversely associated with breast density (p-value for trend <0.01, respectively), whereas nulliparous and premenopausal status were positively associated. Compared to women who had ≥2 children, nulliparous women had an 11.8-fold increase of dense breasts (p-value for trend <0.01). Compared to postmenopausal women, premenopausal women had 2.4-fold increase of dense breasts (odds ratio, 2.42; 95% confidence interval, 1.36 to 4.32). CONCLUSION: Young age, lower body mass index, lower parity, and premenopausal status were significantly associated with dense breasts in Korea
Files in This Item:
T201194355.pdf Download
DOI
10.4143/crt.2011.43.1.42
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Park, Eun-Cheol(박은철) ORCID logo https://orcid.org/0000-0002-2306-5398
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95472
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