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Elevated osteoprotegerin is associated with inflammation, malnutrition and new onset cardiovascular events in peritoneal dialysis patients.

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dc.contributor.author강신욱-
dc.contributor.author구향모-
dc.contributor.author김승준-
dc.contributor.author김은진-
dc.contributor.author김좌경-
dc.contributor.author도화미-
dc.contributor.author박정탁-
dc.contributor.author오형중-
dc.contributor.author유동은-
dc.contributor.author유태현-
dc.contributor.author이미정-
dc.contributor.author최규헌-
dc.contributor.author한승혁-
dc.date.accessioned2014-12-20T17:52:54Z-
dc.date.available2014-12-20T17:52:54Z-
dc.date.issued2011-
dc.identifier.issn0021-9150-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/95433-
dc.description.abstractBACKGROUNDS: Osteoprotegerin (OPG) is known to regulate bone mineral metabolism and to be also associated with inflammation, cardiovascular disease (CVD) and mortality. Malnutrition-inflammation-atherosclerosis (MIA) syndrome is commonly found and closely linked to mortality in dialysis patients. The aim of this study was to investigate the associations between OPG and MIA syndrome in prevalent peritoneal dialysis (PD) patients. METHODS: Prevalent PD patients for more than 6 months were prospectively followed up from March 2005 to May 2010. At baseline, OPG, hs-CRP, albumin, and %lean body mass (LBM) by creatinine kinetics were checked, and subjective global assessment (SGA) was performed. New-onset cardiovascular events were evaluated during the study period. Based on the median level of OPG, patients were classified as lower OPG (LO) group (n = 88) and higher OPG (HO) group (n = 88). RESULTS: A total of 176 patients (age 52.0 ± 11.8 years, male 50.6%, duration of PD 105.3 ± 67.2 months) were recruited and followed. In HO group, age, hs-CRP level and Charlson's comorbidity indices were higher, whereas serum albumin level, %LBM and SGA score were significantly lower than LO group. OPG levels were positively correlated with inflammatory markers, whereas negatively correlated with nutritional status. Cardiovascular events occurred in 51 patients during the study period. Newly developed cardiovascular events were significantly common in HO group (n = 36, 40.9%) than LO group (n = 15, 17%, p = 0.002). Cox regression analysis revealed that higher OPG level (per 1-SD increase in OPG, HR: 1.44; 95% CI: 1.03-2.00; p = 0.034) was a significant risk factor for cardiovascular events even after adjustments for demographic and biochemical parameters. CONCLUSION: OPG was significantly correlated with markers of systemic inflammation and malnutrition and was a significant predictor of CVD in PD patients. These findings suggest OPG might be a prognostic indicator of MIA syndrome in prevalent PD patients-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfATHEROSCLEROSIS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHBody Composition-
dc.subject.MESHC-Reactive Protein/metabolism-
dc.subject.MESHCardiovascular Diseases/blood-
dc.subject.MESHCardiovascular Diseases/etiology*-
dc.subject.MESHCardiovascular Diseases/mortality-
dc.subject.MESHComorbidity-
dc.subject.MESHCreatinine/blood-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInflammation/blood-
dc.subject.MESHInflammation/etiology*-
dc.subject.MESHInflammation/mortality-
dc.subject.MESHInflammation Mediators/blood-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHMale-
dc.subject.MESHMalnutrition/blood-
dc.subject.MESHMalnutrition/etiology*-
dc.subject.MESHMalnutrition/mortality-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOsteoprotegerin/blood*-
dc.subject.MESHPeritoneal Dialysis/adverse effects*-
dc.subject.MESHPeritoneal Dialysis/mortality-
dc.subject.MESHPrognosis-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHProspective Studies-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRisk Assessment-
dc.subject.MESHRisk Factors-
dc.subject.MESHSerum Albumin/metabolism-
dc.subject.MESHTime Factors-
dc.subject.MESHUp-Regulation-
dc.titleElevated osteoprotegerin is associated with inflammation, malnutrition and new onset cardiovascular events in peritoneal dialysis patients.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHyang Mo Koo-
dc.contributor.googleauthorHwa Mi Do-
dc.contributor.googleauthorEun Jin Kim-
dc.contributor.googleauthorMi Jung Lee-
dc.contributor.googleauthorDong Ho Shin-
dc.contributor.googleauthorSeung Jun Kim-
dc.contributor.googleauthorHyung Jung Oh-
dc.contributor.googleauthorDong Eun Yoo-
dc.contributor.googleauthorJwa-Kyung Kim-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorKyu Hun Choi-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.identifier.doi10.1016/j.atherosclerosis.2011.09.025-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00053-
dc.contributor.localIdA00203-
dc.contributor.localIdA00931-
dc.contributor.localIdA01315-
dc.contributor.localIdA01654-
dc.contributor.localIdA02097-
dc.contributor.localIdA02417-
dc.contributor.localIdA02461-
dc.contributor.localIdA02526-
dc.contributor.localIdA04043-
dc.contributor.localIdA04304-
dc.contributor.localIdA00659-
dc.contributor.localIdA00823-
dc.contributor.localIdA02773-
dc.relation.journalcodeJ00260-
dc.identifier.eissn1879-1484-
dc.identifier.pmid22015178-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0021915011009312-
dc.subject.keywordOsteoprotegerin-
dc.subject.keywordInflammation-
dc.subject.keywordCardiovascular events-
dc.subject.keywordPeritoneal dialysis-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameKoo, Hyang Mo-
dc.contributor.alternativeNameKim, Seung Jun-
dc.contributor.alternativeNameKim, Eun Jin-
dc.contributor.alternativeNameKim, Jwa Kyung-
dc.contributor.alternativeNameDoh, Fa Mee-
dc.contributor.alternativeNamePark, Jung Tak-
dc.contributor.alternativeNameShin, Dong Ho-
dc.contributor.alternativeNameOh, Hyung Jung-
dc.contributor.alternativeNameYoo, Dong Eun-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.alternativeNameLee, Mi Jung-
dc.contributor.alternativeNameChoi, Kyu Hun-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorKoo, Hyang Mo-
dc.contributor.affiliatedAuthorKim, Jwa Kyung-
dc.contributor.affiliatedAuthorDoh, Fa Mee-
dc.contributor.affiliatedAuthorPark, Jung Tak-
dc.contributor.affiliatedAuthorShin, Dong Ho-
dc.contributor.affiliatedAuthorOh, Hyung Jung-
dc.contributor.affiliatedAuthorYoo, Dong Eun-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorChoi, Kyu Hun-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.contributor.affiliatedAuthorKim, Seung Jun-
dc.contributor.affiliatedAuthorKim, Eun Jin-
dc.contributor.affiliatedAuthorLee, Mi Jung-
dc.rights.accessRightsnot free-
dc.citation.volume219-
dc.citation.number2-
dc.citation.startPage925-
dc.citation.endPage930-
dc.identifier.bibliographicCitationATHEROSCLEROSIS, Vol.219(2) : 925-930, 2011-
dc.identifier.rimsid40815-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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