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Rab25 as a tumour suppressor in colon carcinogenesis

Authors
 JR Goldenring  ;  KT Nam 
Citation
 BRITISH JOURNAL OF CANCER, Vol.104(1) : 33-36, 2011 
Journal Title
 BRITISH JOURNAL OF CANCER 
ISSN
 0007-0920 
Issue Date
2011
MeSH
Animals ; Colonic Neoplasms/metabolism* ; Colonic Neoplasms/pathology ; Humans ; Mice ; Proteins/physiology* ; Tumor Suppressor Proteins/physiology* ; rab GTP-Binding Proteins/physiology*
Keywords
Rab proteins ; colon cancer ; vesicle trafficking ; Rab11-FIP ; integrin ; Smad3
Abstract
Recent investigations have increasingly focussed attention on the roles of intracellular vesicle trafficking in the regulation of epithelial polarity and transformation. Rab25, an epithelial-specific member of the Rab family of small GTPases, has been associated with several epithelial cancers. Whereas Rab25 overexpression is associated with ovarian cancer aggressive behaviour, Rab25 expression is decreased in human colon cancers independent of stage. Recent studies of mouse models of intestinal and colonic neoplasia have demonstrated that Rab25 deficiency markedly promotes the development of neoplasia. Some of these effects appear related to alterations in β1-integrin trafficking to the cell surface. These findings all suggest that Rab25 is a tumour suppressor for colonic neoplasia.
Files in This Item:
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DOI
10.1038/sj.bjc.6605983
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Nam, Ki Taek(남기택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95425
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