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The positive association between peripheral blood cell counts and bone mineral density in postmenopausal women.

Authors
 Hack-Lyoung Kim  ;  Hwa Young Cho  ;  In Young Park  ;  Jin Man Choi  ;  Min Kim  ;  Ho Jin Jang  ;  Se-Min Hwang 
Citation
 YONSEI MEDICAL JOURNAL, Vol.52(5) : 739-745, 2011 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2011
MeSH
Aged ; Blood Cell Count* ; Bone Density* ; Female ; Hematopoiesis ; Humans ; Linear Models ; Middle Aged ; Osteogenesis ; Postmenopause/blood* ; Postmenopause/metabolism* ; Republic of Korea
Keywords
Association ; blood cells ; bone density ; postmenopause
Abstract
PURPOSE: Accumulating evidence has shown a close connection between hematopoiesis and bone formation. Our aim was to evaluate the association between peripheral blood cell counts and bone mineral density (BMD) in a sample of postmenopausal women. MATERIALS AND METHODS: Three hundreds thirty eight healthy postmenopausal women who underwent BMD measurement during their health check-up were investigated. BMD was measured by dual energy X-ray asorptiometry at L1-L4 spine, femoral neck and total proximal femur. BMD was expressed as a T-score: among T-scores obtained from three different sites (L1-L4 spine, femoral neck and total proximal femur), the lowest T-score was considered to be the subject's T-score. RESULTS: The prevalence of osteopenia and osteoporosis diagnosed by T-score in the study participants were 49.4% (167/338) and 5.0% (17/338), respectively. Peripheral blood white blood cell (WBC), red blood cell (RBC) and platelet counts had significant positive correlations with T-scores (p<0.001) upon simple linear regression analysis. A multiple linear regression analysis, after controlling of confounders including age, body weight, systolic blood pressure, alkaline phosphatase and creatinine, showed that WBC (β=0.127; standard error=0.043; p=0.014), RBC (β=0.192; standard error=0.139; p<0.001) and platelet (β=0.097; standard error=0.001; p=0.050) counts still had significant positive association with T-scores. CONCLUSION: The study results showed a positive relationship between blood cell counts and bone mineral density in postmenopausal women, supporting the idea of a close connection between hematopoiesis and bone formation. The study results also suggest that blood cell counts could be a putative marker for estimating BMD in postmenopausal women.
Files in This Item:
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DOI
10.3349/ymj.2011.52.5.739
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min(김민) ORCID logo https://orcid.org/0000-0003-1873-6959
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95390
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