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The effect of succinylated atelocollagen and ablative fractional resurfacing laser on striae distensae

Authors
 Jung U Shin  ;  Mi Ryung Roh  ;  Dong Kyun Rah  ;  Nam Kyoung Ae  ;  Hwal Suh  ;  Kee Yang Chung 
Citation
 JOURNAL OF DERMATOLOGICAL TREATMENT, Vol.22(2) : 113-121, 2011 
Journal Title
 JOURNAL OF DERMATOLOGICAL TREATMENT 
ISSN
 0954-6634 
Issue Date
2011
MeSH
Cicatrix/drug therapy* ; Cicatrix/pathology ; Cicatrix/surgery* ; Collagen/therapeutic use* ; Combined Modality Therapy ; Double-Blind Method ; Female ; Humans ; Laser Therapy* ; Lasers, Gas/therapeutic use* ; Treatment Outcome
Keywords
ablative fractional laser ; collagen ; striae distensae
Abstract
Striae distensae are dermal atrophic scars with epidermal thinning and decreased collagen and elastic fiber. There is no 'gold standard' treatment modality in the treatment of striae distensae. Collagen is a major extracellular matrix component and is important in wound healing. The ablative CO(2) fractional laser is effective in various cutaneous scars and this study was attempted to evaluate the effect of succinylated atelocollagen and ablative CO(2) fractional laser in the treatment of striae distensae. Participants were divided into two groups and received three laser treatments at a 4-week interval. Clinical improvement was evaluated by participants and two blinded physicians by observing the comparative photographs. Skin biopsies were randomly taken from six participants. The ablative fractional resurfacing laser was effective in the clinical improvement of striae distensae. Statistically significant differences were partly observed between the collagen and placebo groups. Clinical improvement scored by doctors showed more improvement in the collagen group. However, scoring by participants did not show significant differences between the collagen and placebo groups. In conclusion, the ablative fractional resurfacing laser is effective in the treatment of striae distensae and succinylated atelocollagen may also be effective for striae distensae treatment. However, to prove the effect of succinylated atelocollagen, further research with a larger group of participants is needed.
Full Text
http://informahealthcare.com/doi/abs/10.3109/09546630903476902
DOI
10.3109/09546630903476902
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Rah, Dong Kyun(나동균)
Roh, Mi Ryung(노미령) ORCID logo https://orcid.org/0000-0002-6285-2490
Suh, Hwal(서활)
Shin, Jung U(신정우) ORCID logo https://orcid.org/0000-0001-5259-6879
Chung, Kee Yang(정기양) ORCID logo https://orcid.org/0000-0003-3257-0297
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95385
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