Cited 0 times in
Prognostic factors for idiopathic pulmonary fibrosis: clinical, physiologic, pathologic, and molecular aspects
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상국 | - |
dc.contributor.author | 이상훈 | - |
dc.contributor.author | 임주은 | - |
dc.contributor.author | 장준 | - |
dc.contributor.author | 정지예 | - |
dc.contributor.author | 강영애 | - |
dc.contributor.author | 김세규 | - |
dc.contributor.author | 김송이 | - |
dc.contributor.author | 김영삼 | - |
dc.contributor.author | 김은영 | - |
dc.contributor.author | 박무석 | - |
dc.contributor.author | 박병훈 | - |
dc.contributor.author | 손지영 | - |
dc.contributor.author | 이경종 | - |
dc.date.accessioned | 2014-12-20T17:51:03Z | - |
dc.date.available | 2014-12-20T17:51:03Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1124-0490 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95374 | - |
dc.description.abstract | BACKGROUND: Previous studies identified clinical and physiologic factors of idiopathic pulmonary fibrosis (IPF) that are related to an increased risk of mortality. But there are few studies about histologic and molecular approach. OBJECTIVE: We investigated whether the C-reactive protein (CRP), fibroblastic foci, phosphorylated Smad2/3 (p-Smad2/3), tumor growth factor-beta (TGF-beta), TGF-beta receptor II (TbetaRII), and the polymorphism of the TGF-beta1 codon 10 are associated with the progression of IPF patients. DESIGN: Eighty-six IPF patients who underwent surgical lung biopsies were examined. For each patient, clinical and physiologic parameters were investigated, and we performed immunohistochemical staining for p-Smad2/3 and TbetaRII, and genotyping of the TGF-beta1 codon 10 polymorphism. RESULTS: Age at diagnosis, gender, symptom duration, and smoking status did not show a significant association. However, the amount of smoking (p = 0.002), severe reduction in the percentages of predicted forced vital capacity (p = 0.013) and diffusion lung capacity of carbon monoxide (p = 0.023), CRP (p = 0.009) at diagnosis, and fibroblastic foci (p = 0.026) were associated with a poor prognosis. Cellularity, fibrosis, expression level of p-Smad2/3 and TbetaRII, and genotype of the TGF-beta1 codon 10 polymorphism did not have a statistically significant association with the prognosis. CONCLUSION: This study confirmed the amount of smoking, abrupt decrease in follow-up pulmonary function parameters, fibroblastic foci, and increased levels of CRP concentration at diagnosis were significantly associated with poor survival. Larger studies are required to confirm all prognostic factors including CRP. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers/analysis | - |
dc.subject.MESH | Biopsy | - |
dc.subject.MESH | C-Reactive Protein/analysis | - |
dc.subject.MESH | Codon | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibroblasts/pathology | - |
dc.subject.MESH | Forced Expiratory Volume | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Idiopathic Pulmonary Fibrosis/diagnosis* | - |
dc.subject.MESH | Idiopathic Pulmonary Fibrosis/genetics | - |
dc.subject.MESH | Idiopathic Pulmonary Fibrosis/metabolism | - |
dc.subject.MESH | Idiopathic Pulmonary Fibrosis/mortality | - |
dc.subject.MESH | Idiopathic Pulmonary Fibrosis/pathology | - |
dc.subject.MESH | Idiopathic Pulmonary Fibrosis/physiopathology | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Lung*/chemistry | - |
dc.subject.MESH | Lung*/pathology | - |
dc.subject.MESH | Lung*/physiopathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Phosphorylation | - |
dc.subject.MESH | Polymerase Chain Reaction | - |
dc.subject.MESH | Polymorphism, Genetic | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Protein-Serine-Threonine Kinases/analysis | - |
dc.subject.MESH | Receptors, Transforming Growth Factor beta/analysis | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Smad2 Protein/analysis | - |
dc.subject.MESH | Smad3 Protein/analysis | - |
dc.subject.MESH | Smoking/adverse effects | - |
dc.subject.MESH | Transforming Growth Factor beta1/analysis | - |
dc.subject.MESH | Transforming Growth Factor beta1/genetics | - |
dc.subject.MESH | Vital Capacity | - |
dc.title | Prognostic factors for idiopathic pulmonary fibrosis: clinical, physiologic, pathologic, and molecular aspects | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | S.H. Lee | - |
dc.contributor.googleauthor | H.S. Shim | - |
dc.contributor.googleauthor | S.H. Cho | - |
dc.contributor.googleauthor | S.Y. Kim | - |
dc.contributor.googleauthor | S.K. Lee | - |
dc.contributor.googleauthor | J.Y. Son | - |
dc.contributor.googleauthor | J.Y. Jung | - |
dc.contributor.googleauthor | E.Y. Kim | - |
dc.contributor.googleauthor | , J.E. Lim | - |
dc.contributor.googleauthor | K.J. Lee | - |
dc.contributor.googleauthor | B.H. Park | - |
dc.contributor.googleauthor | Y.A. Kang | - |
dc.contributor.googleauthor | Y.S. Kim | - |
dc.contributor.googleauthor | S.K. Kim | - |
dc.contributor.googleauthor | J. Chang | - |
dc.contributor.googleauthor | M.S. Park | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02809 | - |
dc.contributor.localId | A03407 | - |
dc.contributor.localId | A03472 | - |
dc.contributor.localId | A03735 | - |
dc.contributor.localId | A00057 | - |
dc.contributor.localId | A00602 | - |
dc.contributor.localId | A00626 | - |
dc.contributor.localId | A00707 | - |
dc.contributor.localId | A01457 | - |
dc.contributor.localId | A01478 | - |
dc.contributor.localId | A01996 | - |
dc.contributor.localId | A02219 | - |
dc.contributor.localId | A03825 | - |
dc.contributor.localId | A02836 | - |
dc.contributor.localId | A00811 | - |
dc.contributor.localId | A02654 | - |
dc.relation.journalcode | J02628 | - |
dc.identifier.pmid | 22117501 | - |
dc.identifier.url | http://www.sarcoidosis.it/data/2011/2_2011.html | - |
dc.subject.keyword | idiopathic pulmonary fibrosis | - |
dc.subject.keyword | C-reactive protein | - |
dc.subject.keyword | Smad | - |
dc.subject.keyword | TGF-β | - |
dc.subject.keyword | survival | - |
dc.subject.keyword | prognosis | - |
dc.subject.keyword | risk factor | - |
dc.contributor.alternativeName | Lee, Sang Kook | - |
dc.contributor.alternativeName | Lee, Sang Hoon | - |
dc.contributor.alternativeName | Lim, Ju Eun | - |
dc.contributor.alternativeName | Chang, Joon | - |
dc.contributor.alternativeName | Jung, Ji Ye | - |
dc.contributor.alternativeName | Kang, Young Ae | - |
dc.contributor.alternativeName | Kim, Se Kyu | - |
dc.contributor.alternativeName | Kim, Song Yi | - |
dc.contributor.alternativeName | Kim, Young Sam | - |
dc.contributor.alternativeName | Kim, Eun Young | - |
dc.contributor.alternativeName | Park, Moo Suk | - |
dc.contributor.alternativeName | Park, Byung Hoon | - |
dc.contributor.alternativeName | Son, Ji Young | - |
dc.contributor.alternativeName | Lee, Kyung Jong | - |
dc.contributor.affiliatedAuthor | Lee, Sang Kook | - |
dc.contributor.affiliatedAuthor | Lim, Ju Eun | - |
dc.contributor.affiliatedAuthor | Chang, Joon | - |
dc.contributor.affiliatedAuthor | Jung, Ji Ye | - |
dc.contributor.affiliatedAuthor | Kang, Young Ae | - |
dc.contributor.affiliatedAuthor | Kim, Se Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Song Yi | - |
dc.contributor.affiliatedAuthor | Kim, Young Sam | - |
dc.contributor.affiliatedAuthor | Park, Moo Suk | - |
dc.contributor.affiliatedAuthor | Park, Byung Hoon | - |
dc.contributor.affiliatedAuthor | Son, Ji Young | - |
dc.contributor.affiliatedAuthor | Lee, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Eun Young | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Jong | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 28 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 102 | - |
dc.citation.endPage | 112 | - |
dc.identifier.bibliographicCitation | SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, Vol.28(2) : 102-112, 2011 | - |
dc.identifier.rimsid | 48328 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.