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Mycobacterium tuberculosislpdC, Rv0462, induces dendritic cell maturation and Th1 polarization

Authors
 Deok Rim Heo  ;  Sung Jae Shin  ;  Woo Sik Kim  ;  Kyung Tae Noh  ;  Jin Wook Park  ;  Kwang Hee Son  ;  Won Sun Park  ;  Min-Goo Lee  ;  Daejin Kim  ;  Yong Kyoo Shin  ;  In Duk Jung  ;  Yeong-Min Park 
Citation
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.411(3) : 642-647, 2011 
Journal Title
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 
ISSN
 0006-291X 
Issue Date
2011
MeSH
Animals ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Polarity/immunology* ; Dendritic Cells/immunology* ; Dihydrolipoamide Dehydrogenase/genetics ; Dihydrolipoamide Dehydrogenase/immunology* ; Humans ; Immunity, Innate ; Interleukin-12/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Mycobacterium tuberculosis/enzymology ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/immunology* ; Th1 Cells/immunology* ; Tuberculosis/metabolism* ; Tuberculosis/microbiology
Keywords
Dendritic cells ; Th1 polarization ; MAPKs ; Mycobacterium tuberculosis ; Rv0462
Abstract
Mycobacterium tuberculosis, the etiological factor of pulmonary tuberculosis, causes significant morbidity and mortality worldwide. Activation of host immune responses for containment of mycobacterial infections involves participation of innate immune cells, such as dendritic cells (DCs). In this study, we demonstrated that the gene encoding lipoamide dehydrogenase C (lpdC) from M. tuberculosis, Rv0462, induce maturation and activation of DCs involved in the MAPKs signaling pathway. Moreover, Rv0462-treated DCs activated naïve T cells, polarized CD4(+) and CD8(+) T cells to secrete IFN-γ in syngeneic mixed lymphocyte reactions, which would be expected to contribute to Th1 polarization of the immune response. Our results suggest that Rv0462 can contribute to the innate and adaptive immune responses during tuberculosis infection, and thus modulate the clinical course of tuberculosis.
Full Text
http://www.sciencedirect.com/science/article/pii/S0006291X11012320
DOI
10.1016/j.bbrc.2011.07.013
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Shin, Sung Jae(신성재) ORCID logo https://orcid.org/0000-0003-0854-4582
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95345
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