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FrsA functions as a cofactor-independent decarboxylase to control metabolic flux

DC Field Value Language
dc.contributor.author박순정-
dc.date.accessioned2014-12-20T17:49:17Z-
dc.date.available2014-12-20T17:49:17Z-
dc.date.issued2011-
dc.identifier.issn1552-4450-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/95317-
dc.description.abstractThe interaction between fermentation-respiration switch (FrsA) protein and glucose-specific enzyme IIA(Glc) increases glucose fermentation under oxygen-limited conditions. We show that FrsA converts pyruvate to acetaldehyde and carbon dioxide in a cofactor-independent manner and that its pyruvate decarboxylation activity is enhanced by the dephosphorylated form of IIA(Glc) (d-IIA(Glc)). Crystal structures of FrsA and its complex with d-IIA(Glc) revealed residues required for catalysis as well as the structural basis for the activation by d-IIA(Glc).-
dc.description.statementOfResponsibilityopen-
dc.format.extent434~436-
dc.relation.isPartOfNATURE CHEMICAL BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcetaldehyde/metabolism-
dc.subject.MESHAnimals-
dc.subject.MESHBase Sequence-
dc.subject.MESHCarbon Dioxide/metabolism-
dc.subject.MESHCarboxy-Lyases/chemistry-
dc.subject.MESHCarboxy-Lyases/genetics-
dc.subject.MESHCarboxy-Lyases/metabolism*-
dc.subject.MESHCarboxy-Lyases/pharmacology-
dc.subject.MESHCrystallography, X-Ray-
dc.subject.MESHDecarboxylation-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHElectrophoresis, Polyacrylamide Gel-
dc.subject.MESHEscherichia coli/genetics-
dc.subject.MESHEscherichia coli/growth & development-
dc.subject.MESHEscherichia coli/metabolism-
dc.subject.MESHEscherichia coli Proteins/chemistry-
dc.subject.MESHEscherichia coli Proteins/genetics-
dc.subject.MESHEscherichia coli Proteins/metabolism*-
dc.subject.MESHFemale-
dc.subject.MESHFermentation-
dc.subject.MESHGlucose/metabolism*-
dc.subject.MESHKinetics-
dc.subject.MESHMagnetic Resonance Spectroscopy-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHModels, Molecular-
dc.subject.MESHMolecular Sequence Data-
dc.subject.MESHMutagenesis, Site-Directed-
dc.subject.MESHPhosphoenolpyruvate Sugar Phosphotransferase System/chemistry-
dc.subject.MESHPhosphoenolpyruvate Sugar Phosphotransferase System/genetics-
dc.subject.MESHPhosphoenolpyruvate Sugar Phosphotransferase System/metabolism*-
dc.subject.MESHProtein Conformation-
dc.subject.MESHPyruvic Acid/metabolism*-
dc.subject.MESHRecombinant Proteins/chemistry-
dc.subject.MESHRecombinant Proteins/genetics-
dc.subject.MESHRecombinant Proteins/metabolism*-
dc.subject.MESHRecombinant Proteins/pharmacology-
dc.subject.MESHSubstrate Specificity-
dc.subject.MESHVibrio vulnificus/genetics-
dc.subject.MESHVibrio vulnificus/metabolism-
dc.subject.MESHVibrio vulnificus/pathogenicity-
dc.subject.MESHVirulence-
dc.titleFrsA functions as a cofactor-independent decarboxylase to control metabolic flux-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Environmental Medical Biology (환경의생물학)-
dc.contributor.googleauthorKyung-Jo Lee-
dc.contributor.googleauthorChang-Sook Jeong-
dc.contributor.googleauthorYoung Jun An-
dc.contributor.googleauthorHyun-Jung Lee-
dc.contributor.googleauthorSoon-Jung Park-
dc.contributor.googleauthorYeong-Jae Seok-
dc.contributor.googleauthorPil Kim-
dc.contributor.googleauthorJung-Hyun Lee-
dc.contributor.googleauthorKyu-Ho Lee-
dc.contributor.googleauthorSun-Shin Cha-
dc.identifier.doi10.1038/nchembio.589-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01545-
dc.relation.journalcodeJ02292-
dc.identifier.eissn1552-4469-
dc.identifier.pmid21623357-
dc.identifier.urlhttp://www.nature.com/nchembio/journal/v7/n7/full/nchembio.589.html-
dc.contributor.alternativeNamePark, Soon Jung-
dc.contributor.affiliatedAuthorPark, Soon Jung-
dc.rights.accessRightsnot free-
dc.citation.volume7-
dc.citation.number7-
dc.citation.startPage434-
dc.citation.endPage436-
dc.identifier.bibliographicCitationNATURE CHEMICAL BIOLOGY, Vol.7(7) : 434-436, 2011-
dc.identifier.rimsid31402-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Tropica Medicine (열대의학교실) > 1. Journal Papers
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