Cited 21 times in
FrsA functions as a cofactor-independent decarboxylase to control metabolic flux
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박순정 | - |
dc.date.accessioned | 2014-12-20T17:49:17Z | - |
dc.date.available | 2014-12-20T17:49:17Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1552-4450 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95317 | - |
dc.description.abstract | The interaction between fermentation-respiration switch (FrsA) protein and glucose-specific enzyme IIA(Glc) increases glucose fermentation under oxygen-limited conditions. We show that FrsA converts pyruvate to acetaldehyde and carbon dioxide in a cofactor-independent manner and that its pyruvate decarboxylation activity is enhanced by the dephosphorylated form of IIA(Glc) (d-IIA(Glc)). Crystal structures of FrsA and its complex with d-IIA(Glc) revealed residues required for catalysis as well as the structural basis for the activation by d-IIA(Glc). | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 434~436 | - |
dc.relation.isPartOf | NATURE CHEMICAL BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acetaldehyde/metabolism | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Base Sequence | - |
dc.subject.MESH | Carbon Dioxide/metabolism | - |
dc.subject.MESH | Carboxy-Lyases/chemistry | - |
dc.subject.MESH | Carboxy-Lyases/genetics | - |
dc.subject.MESH | Carboxy-Lyases/metabolism* | - |
dc.subject.MESH | Carboxy-Lyases/pharmacology | - |
dc.subject.MESH | Crystallography, X-Ray | - |
dc.subject.MESH | Decarboxylation | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Electrophoresis, Polyacrylamide Gel | - |
dc.subject.MESH | Escherichia coli/genetics | - |
dc.subject.MESH | Escherichia coli/growth & development | - |
dc.subject.MESH | Escherichia coli/metabolism | - |
dc.subject.MESH | Escherichia coli Proteins/chemistry | - |
dc.subject.MESH | Escherichia coli Proteins/genetics | - |
dc.subject.MESH | Escherichia coli Proteins/metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fermentation | - |
dc.subject.MESH | Glucose/metabolism* | - |
dc.subject.MESH | Kinetics | - |
dc.subject.MESH | Magnetic Resonance Spectroscopy | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred ICR | - |
dc.subject.MESH | Models, Molecular | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Mutagenesis, Site-Directed | - |
dc.subject.MESH | Phosphoenolpyruvate Sugar Phosphotransferase System/chemistry | - |
dc.subject.MESH | Phosphoenolpyruvate Sugar Phosphotransferase System/genetics | - |
dc.subject.MESH | Phosphoenolpyruvate Sugar Phosphotransferase System/metabolism* | - |
dc.subject.MESH | Protein Conformation | - |
dc.subject.MESH | Pyruvic Acid/metabolism* | - |
dc.subject.MESH | Recombinant Proteins/chemistry | - |
dc.subject.MESH | Recombinant Proteins/genetics | - |
dc.subject.MESH | Recombinant Proteins/metabolism* | - |
dc.subject.MESH | Recombinant Proteins/pharmacology | - |
dc.subject.MESH | Substrate Specificity | - |
dc.subject.MESH | Vibrio vulnificus/genetics | - |
dc.subject.MESH | Vibrio vulnificus/metabolism | - |
dc.subject.MESH | Vibrio vulnificus/pathogenicity | - |
dc.subject.MESH | Virulence | - |
dc.title | FrsA functions as a cofactor-independent decarboxylase to control metabolic flux | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Environmental Medical Biology (환경의생물학) | - |
dc.contributor.googleauthor | Kyung-Jo Lee | - |
dc.contributor.googleauthor | Chang-Sook Jeong | - |
dc.contributor.googleauthor | Young Jun An | - |
dc.contributor.googleauthor | Hyun-Jung Lee | - |
dc.contributor.googleauthor | Soon-Jung Park | - |
dc.contributor.googleauthor | Yeong-Jae Seok | - |
dc.contributor.googleauthor | Pil Kim | - |
dc.contributor.googleauthor | Jung-Hyun Lee | - |
dc.contributor.googleauthor | Kyu-Ho Lee | - |
dc.contributor.googleauthor | Sun-Shin Cha | - |
dc.identifier.doi | 10.1038/nchembio.589 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01545 | - |
dc.relation.journalcode | J02292 | - |
dc.identifier.eissn | 1552-4469 | - |
dc.identifier.pmid | 21623357 | - |
dc.identifier.url | http://www.nature.com/nchembio/journal/v7/n7/full/nchembio.589.html | - |
dc.contributor.alternativeName | Park, Soon Jung | - |
dc.contributor.affiliatedAuthor | Park, Soon Jung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 7 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 434 | - |
dc.citation.endPage | 436 | - |
dc.identifier.bibliographicCitation | NATURE CHEMICAL BIOLOGY, Vol.7(7) : 434-436, 2011 | - |
dc.identifier.rimsid | 31402 | - |
dc.type.rims | ART | - |
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