Cited 4 times in
Local anesthetics inhibit tissue factor expression in activated monocytes via inhibition of tissue factor mRNA synthesis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김기준 | - |
dc.date.accessioned | 2014-12-20T17:48:54Z | - |
dc.date.available | 2014-12-20T17:48:54Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1076-0296 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95304 | - |
dc.description.abstract | Local anesthetics have been reported to have anticoagulant properties, but the mechanisms responsible for this action are poorly understood. Here, we evaluated the in vitro effects of 3 local anesthetics--lidocaine, ropivacaine, and bupivacaine--on the tissue factor expression by monocytes. Monocytes from peripheral blood were stimulated with lipopolysaccharide (LPS) in the presence or absence of local anesthetics. All 3 local anesthetics inhibited the expression of tissue factor antigen and tissue factor activity in LPS-stimulated monocytes in a dose- and time-dependent manner and reduced tissue factor messenger RNA (mRNA) expression in endothelial cells and a monocytic cell line. None of the 3 drugs induced apoptosis or affected the viability of monocytes. Our findings that local anesthetics inhibited the tissue factor induction in activated monocytes by inhibiting tissue factor mRNA level may demonstrate the feasibility of using local anesthetics in hypercoagulable and inflammatory conditions | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | E4~E9 | - |
dc.relation.isPartOf | CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anesthetics, Local/pharmacology | - |
dc.subject.MESH | Apoptosis | - |
dc.subject.MESH | Bupivacaine/pharmacology | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Endothelial Cells/cytology | - |
dc.subject.MESH | Endothelial Cells/drug effects | - |
dc.subject.MESH | Endothelial Cells/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lidocaine/pharmacology | - |
dc.subject.MESH | Lipopolysaccharides/pharmacology | - |
dc.subject.MESH | Monocytes/cytology | - |
dc.subject.MESH | Monocytes/drug effects* | - |
dc.subject.MESH | Monocytes/metabolism | - |
dc.subject.MESH | RNA, Messenger/antagonists & inhibitors* | - |
dc.subject.MESH | RNA, Messenger/biosynthesis | - |
dc.subject.MESH | RNA, Messenger/blood | - |
dc.subject.MESH | RNA, Messenger/genetics | - |
dc.subject.MESH | Thromboplastin/antagonists & inhibitors* | - |
dc.subject.MESH | Thromboplastin/biosynthesis | - |
dc.subject.MESH | Thromboplastin/genetics | - |
dc.title | Local anesthetics inhibit tissue factor expression in activated monocytes via inhibition of tissue factor mRNA synthesis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Ji-Eun Kim | - |
dc.contributor.googleauthor | Ki Jun Kim | - |
dc.contributor.googleauthor | Wonsik Ahn | - |
dc.contributor.googleauthor | Kyou-Sup Han | - |
dc.contributor.googleauthor | Hyun Kyung Kim | - |
dc.identifier.doi | 10.1177/1076029610378500 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00340 | - |
dc.relation.journalcode | J00546 | - |
dc.identifier.eissn | 1938-2723 | - |
dc.identifier.pmid | 20699252 | - |
dc.identifier.url | http://cat.sagepub.com/content/17/6/E4 | - |
dc.subject.keyword | hemostasis | - |
dc.subject.keyword | anticoagulants | - |
dc.subject.keyword | hypercoagulability | - |
dc.contributor.alternativeName | Kim, Ki Jun | - |
dc.contributor.affiliatedAuthor | Kim, Ki Jun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 17 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 4 | - |
dc.citation.endPage | 9 | - |
dc.identifier.bibliographicCitation | CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, Vol.17(6) : 4-9, 2011 | - |
dc.identifier.rimsid | 31391 | - |
dc.type.rims | ART | - |
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