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Local anesthetics inhibit tissue factor expression in activated monocytes via inhibition of tissue factor mRNA synthesis

DC FieldValueLanguage
dc.contributor.author김기준-
dc.date.accessioned2014-12-20T17:48:54Z-
dc.date.available2014-12-20T17:48:54Z-
dc.date.issued2011-
dc.identifier.issn1076-0296-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/95304-
dc.description.abstractLocal anesthetics have been reported to have anticoagulant properties, but the mechanisms responsible for this action are poorly understood. Here, we evaluated the in vitro effects of 3 local anesthetics--lidocaine, ropivacaine, and bupivacaine--on the tissue factor expression by monocytes. Monocytes from peripheral blood were stimulated with lipopolysaccharide (LPS) in the presence or absence of local anesthetics. All 3 local anesthetics inhibited the expression of tissue factor antigen and tissue factor activity in LPS-stimulated monocytes in a dose- and time-dependent manner and reduced tissue factor messenger RNA (mRNA) expression in endothelial cells and a monocytic cell line. None of the 3 drugs induced apoptosis or affected the viability of monocytes. Our findings that local anesthetics inhibited the tissue factor induction in activated monocytes by inhibiting tissue factor mRNA level may demonstrate the feasibility of using local anesthetics in hypercoagulable and inflammatory conditions-
dc.description.statementOfResponsibilityopen-
dc.format.extentE4~E9-
dc.relation.isPartOfClinical and Applied Thrombosis-Hemostasis-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleLocal anesthetics inhibit tissue factor expression in activated monocytes via inhibition of tissue factor mRNA synthesis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorJi-Eun Kim-
dc.contributor.googleauthorKi Jun Kim-
dc.contributor.googleauthorWonsik Ahn-
dc.contributor.googleauthorKyou-Sup Han-
dc.contributor.googleauthorHyun Kyung Kim-
dc.identifier.doi10.1177/1076029610378500-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00340-
dc.relation.journalcodeJ00546-
dc.identifier.urlhttp://cat.sagepub.com/content/17/6/E4-
dc.contributor.alternativeNameKim, Ki Jun-
dc.contributor.affiliatedAuthorKim, Ki Jun-
dc.rights.accessRightsnot free-
dc.citation.volume17-
dc.citation.number6-
dc.citation.startPage4-
dc.citation.endPage9-
dc.identifier.bibliographicCitationClinical and Applied Thrombosis-Hemostasis, Vol.17(6) : 4-9, 2011-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실)

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