Escherichia coli clinical isolate BD07372 of sequence type ST131 recovered from a bed sore specimen exhibited high-level resistance to ceftazidime and cefotaxime but exhibited susceptibility to imipenem and meropenem. The isolate harbored two β-lactamase genes, the bla(CTX-M-15) gene carried by an ∼250-kbp plasmid carrying the FIA and FIC replicons and the bla(GES-5) gene carried by a class 1 integron in the chromosome