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CKD-712, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Inhibits the NF-κB Activation and Augments Akt Activation during TLR4 Signaling

Authors
 Jeonggi Lee  ;  Eun-Jeong Yang  ;  In-Hong Choi  ;  Sung-Sook Lee  ;  Dal-Hyun Kim  ;  Jeon-Soo Shin 
Citation
 Immune Network, Vol.11(6) : 420-423, 2011 
Journal Title
 Immune Network 
ISSN
 1598-2629 
Issue Date
2011
Abstract
Since CKD-712 has been developed as an anti-inflammatory agent, we examined the effect of CKD-712 during TLR4 signaling. Using HEK293 cells expressing TLR4, CKD-712 was pre-treated 1 hr before LPS stimulation. Activation of NF-κB was assessed by promoter assay. The activation of ERK, JNK, p38, IRF3 and Akt was measured by western blotting. CKD-712 inhibited the NF-κB signaling triggered by LPS. The activation of ERK, JNK, p38 or IRF3 was not inhibited by CKD-712. On the contrary the activation of these molecules was augmented slightly. The activation of Akt with stimulation of LPS was also enhanced with CKD-712 pre-treatment at lower concentration, but was inhibited at higher concentration. We suggest that during TLR4 signaling CKD-712 inhibits NF-κB activation. However, CKD-712 augmented the activation of Akt as well as Map kinases. Therefore, we suggest that CKD-712 might have a role as an immunomodulator
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95243
DOI
10.4110/in.2011.11.6.420
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실)
Yonsei Authors
신전수(Shin, Jeon Soo) ; 최인홍(Choi, In Hong)
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