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Acquisition of a BCR-ABL1 transcript in a patient with disease progression from MDS with fibrosis to AML with myelodysplasia-related changes
DC Field | Value | Language |
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dc.contributor.author | 박서진 | - |
dc.date.accessioned | 2014-12-20T17:44:20Z | - |
dc.date.available | 2014-12-20T17:44:20Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0091-7370 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95169 | - |
dc.description.abstract | The 2008 WHO classification tentatively introduced myelodysplastic syndrome with fibrosis (MDS-F) based on previous literature of the existence of such cases. Most MDS-F cases have increased blasts, lower hemoglobin and platelet counts, an aggressive clinical course, and more frequently include cytogenetic aberrations. We report the case of a 66-year-old male patient diagnosed with refractory anemia with excess blasts-2 with fibrosis (MDS RAEB-2-F) with a normal karyotype and negative findings for both BCR-ABL1 transcript and JAK2 V617F mutations. He refused therapy upon his diagnosis and, after 5 months, his disease progressed to leukemia. The patient was diagnosed with acute myeloid leukemia with myelodysplasia-related changes (AML-MRC), based on a bone marrow exam revealing increased blasts (32.8%). Cytogenetic study revealed a complex karyotype, and molecular studies identified a minor BCRABL1 fusion transcript. The patient's general condition deteriorated despite the initiation of induction chemotherapy, and he died approximately 2 weeks after the diagnosis of AML-MRC. This patient's poor clinical outcome may have been exacerbated by the acquisition of the BCR-ABL1 fusion transcript overlapping with the aggressive nature of MDS-F. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 379~384 | - |
dc.relation.isPartOf | ANNALS OF CLINICAL AND LABORATORY SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Disease Progression* | - |
dc.subject.MESH | Fatal Outcome | - |
dc.subject.MESH | Fibrosis | - |
dc.subject.MESH | Fusion Proteins, bcr-abl/genetics* | - |
dc.subject.MESH | Fusion Proteins, bcr-abl/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | In Situ Hybridization, Fluorescence | - |
dc.subject.MESH | Karyotyping | - |
dc.subject.MESH | Leukemia, Myeloid, Acute/genetics* | - |
dc.subject.MESH | Leukemia, Myeloid, Acute/pathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Myelodysplastic Syndromes/diagnosis | - |
dc.subject.MESH | Myelodysplastic Syndromes/genetics* | - |
dc.subject.MESH | RNA, Messenger/genetics | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.title | Acquisition of a BCR-ABL1 transcript in a patient with disease progression from MDS with fibrosis to AML with myelodysplasia-related changes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Seo-Jin Park | - |
dc.contributor.googleauthor | Hyun Woo Lee | - |
dc.contributor.googleauthor | Seong Hyun Jeong | - |
dc.contributor.googleauthor | Joon Seong Park | - |
dc.contributor.googleauthor | Hugh Chul Kim | - |
dc.contributor.googleauthor | Jae Yeon Seok | - |
dc.contributor.googleauthor | Hyon J. Kim | - |
dc.contributor.googleauthor | Sung Ran Cho | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01494 | - |
dc.relation.journalcode | J00155 | - |
dc.identifier.eissn | 1550-8080 | - |
dc.identifier.pmid | 22166509 | - |
dc.identifier.url | http://www.annclinlabsci.org/content/41/4/379.long | - |
dc.contributor.alternativeName | Park, Seo Jin | - |
dc.contributor.affiliatedAuthor | Park, Seo Jin | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 41 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 379 | - |
dc.citation.endPage | 384 | - |
dc.identifier.bibliographicCitation | ANNALS OF CLINICAL AND LABORATORY SCIENCE, Vol.41(4) : 379-384, 2011 | - |
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