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외인성 아토피피부염과 내인성 아토피피부염 환자의 말초혈액 단핵세포와 피부 병변에서 IL-3와 FcεRI 발현의 차이

Other Titles
 Differential Expressions of IL-3 and FcepsilonRI in the Peripheral Blood Mononuclear Cells and Lesional Skin of Patients with Extrinsic Atopic Dermatitis and Intrinsic Atopic Dermatitis. 
Authors
 김산  ;  노성민  ;  배병기  ;  박창욱  ;  이광훈 
Citation
 Korean Journal of Dermatology (대한피부과학회지), Vol.49(6) : 491-498, 2011 
Journal Title
 Korean Journal of Dermatology  (대한피부과학회지) 
ISSN
 4944-4739 
Issue Date
2011
Abstract
BACKGROUND: A small subgroup of atopic dermatitis (AD) patients show low total and allergen-specific immunoglobulin (IgE) levels. This subgroup has been termed 'intrinsic' AD (IAD) as compared to its counterpart 'extrinsic' AD (EAD). However, the difference of cytokine expression between IAD and EAD has not been fully understood. OBJECTIVE: To compare the expression of various inflammatory cytokines in the peripheral blood mononuclear cells (PBMCs) and lesional skin of patients with IAD and EAD, which are known to be associated with AD pathophysiology. METHODS: We assessed the protein levels of cytokines in the PBMCs and lesional skin. We evaluated the levels of IL-3, IL-4, IL-5, IL-6, IL-10, IL-13, FcepsilonRI and FcepsilonRII from the PBMCs and lesional skin of patients with IAD and EAD. RESULTS: The patients with EAD had elevated levels of the IL-3 expression in their PBMCs and elevated levels of FcepsilonRI in their lesional skin compared to that of the patients with IAD. The expression of other cytokines did not differ in the PBMCs and lesional skin from the two subgroups. CONCLUSION: This study suggests that IL-3 could be associated with the pathophysiology of EAD as compared to that of IAD, along with FcepsilonRI which was previously shown to be highly expressed in EAD patients.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95168
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실)
Yonsei Authors
박창욱(Park, Chang Ook) ; 이광훈(Lee, Kwang Hoon)
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