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Serum cystatin C reflects the progress of albuminuria

 Jeong Seon Yoo ; Young Mi Lee ; Kyung Rae Kim ; Young Duk Song ; Chul Woo Ahn ; Joo Young Nam ; Jong Suk Park ; Shin Ae Kang ; Ki-Cheon Jeong ; Shin Young Lee ; Ji Woon Kim ; Eun Hae Lee 
 Diabetes & Metabolism Journal, Vol.35(6) : 602~609, 2011 
Journal Title
 Diabetes & Metabolism Journal 
Issue Date
BACKGROUND: Research on the relationship between urinary albumin excretion and serum cystatin C in diabetes is restricted to cross-sectional studies. In this study, we investigated how well serial measurements of serum cystatin C level reflect changes in the urinary albumin excretion rate. METHODS: We enrolled and retrospectively collected data on 1,058 participants with type 2 diabetes who were older than 18 years and who had more than 3 years of follow-up with serial measurements of albuminuria and serum cystatin C at an outpatient clinic. RESULTS: With the use of a linear mixed model, we found that the albuminuria level for each patient over time corresponded with the annual change in serum cystatin C-based estimated glomerular filtration rate (cysC-eGFR) but did not correspond with the creatinine-based eGFR calculated by the modification of diet in renal disease formula (MDRD-eGFR). The discrepancy in the direction of the trend was smaller with cysC-eGFR than with MDRD-eGFR. CONCLUSION: Serum cystatin C level reflects the trend in albuminuria level more accurately than serum creatinine level in Korean type 2 diabetes mellitus patients.
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