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Serum cystatin C reflects the progress of albuminuria

Authors
 Jeong Seon Yoo  ;  Young Mi Lee  ;  Eun Hae Lee  ;  Ji Woon Kim  ;  Shin Young Lee  ;  Ki-Cheon Jeong  ;  Shin Ae Kang  ;  Jong Suk Park  ;  Joo Young Nam  ;  Chul Woo Ahn  ;  Young Duk Song  ;  Kyung Rae Kim 
Citation
 DIABETES & METABOLISM JOURNAL, Vol.35(6) : 602-609, 2011 
Journal Title
DIABETES & METABOLISM JOURNAL
ISSN
 2233-6079 
Issue Date
2011
Keywords
Albuminuria ; Creatinine ; Cystatin C ; Diabetes mellitus, type 2 ; Diabetic nephropathies
Abstract
BACKGROUND: Research on the relationship between urinary albumin excretion and serum cystatin C in diabetes is restricted to cross-sectional studies. In this study, we investigated how well serial measurements of serum cystatin C level reflect changes in the urinary albumin excretion rate.

METHODS: We enrolled and retrospectively collected data on 1,058 participants with type 2 diabetes who were older than 18 years and who had more than 3 years of follow-up with serial measurements of albuminuria and serum cystatin C at an outpatient clinic.

RESULTS: With the use of a linear mixed model, we found that the albuminuria level for each patient over time corresponded with the annual change in serum cystatin C-based estimated glomerular filtration rate (cysC-eGFR) but did not correspond with the creatinine-based eGFR calculated by the modification of diet in renal disease formula (MDRD-eGFR). The discrepancy in the direction of the trend was smaller with cysC-eGFR than with MDRD-eGFR.

CONCLUSION: Serum cystatin C level reflects the trend in albuminuria level more accurately than serum creatinine level in Korean type 2 diabetes mellitus patients.
Files in This Item:
T201105346.pdf Download
DOI
10.4093/dmj.2011.35.6.602
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Ae(강신애) ORCID logo https://orcid.org/0000-0002-9719-4774
Kim, Kyung Rae(김경래)
Kim, Ji Woon(김지운) ORCID logo https://orcid.org/0000-0002-0169-5030
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Yoo, Jeong Seon(유정선)
Lee, Shin Young(이신영)
Lee, Eun Hae(이은해)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95154
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