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Serum cystatin C reflects the progress of albuminuria

 Jeong Seon Yoo  ;  Young Mi Lee  ;  Kyung Rae Kim  ;  Young Duk Song  ;  Chul Woo Ahn  ;  Joo Young Nam  ;  Jong Suk Park  ;  Shin Ae Kang  ;  Ki-Cheon Jeong  ;  Shin Young Lee  ;  Ji Woon Kim  ;  Eun Hae Lee 
 Diabetes & Metabolism Journal, Vol.35(6) : 602-609, 2011 
Journal Title
 Diabetes & Metabolism Journal 
Issue Date
BACKGROUND: Research on the relationship between urinary albumin excretion and serum cystatin C in diabetes is restricted to cross-sectional studies. In this study, we investigated how well serial measurements of serum cystatin C level reflect changes in the urinary albumin excretion rate. METHODS: We enrolled and retrospectively collected data on 1,058 participants with type 2 diabetes who were older than 18 years and who had more than 3 years of follow-up with serial measurements of albuminuria and serum cystatin C at an outpatient clinic. RESULTS: With the use of a linear mixed model, we found that the albuminuria level for each patient over time corresponded with the annual change in serum cystatin C-based estimated glomerular filtration rate (cysC-eGFR) but did not correspond with the creatinine-based eGFR calculated by the modification of diet in renal disease formula (MDRD-eGFR). The discrepancy in the direction of the trend was smaller with cysC-eGFR than with MDRD-eGFR. CONCLUSION: Serum cystatin C level reflects the trend in albuminuria level more accurately than serum creatinine level in Korean type 2 diabetes mellitus patients.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강신애(Kang, Shin Ae) ; 김경래(Kim, Kyung Rae) ; 김지운(Kim, Ji Woon) ; 박종숙(Park, Jong Suk) ; 안철우(Ahn, Chul Woo) ; 유정선(Yoo, Jeong Seon) ; 이신영(Lee, Shin Young) ; 이은해(Lee, Eun Hae)
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