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CD4(+) CD25(+) regulatory T cells ameliorate Behcet's disease-like symptoms in a mouse model

DC Field Value Language
dc.contributor.author방동식-
dc.date.accessioned2014-12-20T17:42:24Z-
dc.date.available2014-12-20T17:42:24Z-
dc.date.issued2011-
dc.identifier.issn1465-3249-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/95108-
dc.description.abstractBACKGROUND AIMS: Behcet's disease (BD) is a chronic, multisystemic inflammatory disorder with arthritic, gastrointestinal, mucocutaneous, ocular, vascular and central nervous system involvement. It is well known that CD4(+) CD25(+) T-regulatory (Treg) cells prevent harmful immune responses to self- and non-self-antigens. In the present study, the role of Treg cells in herpes simplex virus (HSV)-induced BD-like symptoms was investigated. METHODS: HSV type 1 (F strain) inoculation of the earlobe of ICR mice has been shown to induce the development of BD-like symptoms. To determine whether the effect of Treg was associated with change in BD-like symptoms, CD4(+) CD25(+) T cells from the splenocytes of normal mice were adoptively transferred intravenously. Treg cells of splenocytes were significantly elevated following the transfer of 3 × 10(5) CD4(+) CD25(+) T cells to BD-like mice compared with the control group. RESULTS: The transfer of CD4(+) CD25(+) T cells to BD mice improved the symptoms, and the serum protein levels of interleukin (IL)-10, IL-6 and IL-17 were significantly altered compared with the control groups. Intravenous injection of anti-CD25 antibody to BD mice reduced the frequency of CD4(+) CD25(+) T cells and increased the BD severity score. We confirmed the influence of CD4(+) CD25(+) T cells on BD-like mice. CONCLUSIONS: These results show that up-regulation of the CD4(+) CD25(+) T cells in BD-like mice improves the inflammatory symptoms, while down-regulation of CD25(+) T cells is associated with deteriorated symptoms. Furthermore, these findings are correlated with changes in pro-inflammatory and anti-inflammatory cytokine levels.-
dc.description.statementOfResponsibilityopen-
dc.format.extent835~847-
dc.relation.isPartOfCYTOTHERAPY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdoptive Transfer-
dc.subject.MESHAnimals-
dc.subject.MESHBehcet Syndrome/immunology*-
dc.subject.MESHBehcet Syndrome/metabolism-
dc.subject.MESHBehcet Syndrome/therapy*-
dc.subject.MESHBehcet Syndrome/virology-
dc.subject.MESHCD4-Positive T-Lymphocytes/immunology*-
dc.subject.MESHCells, Cultured-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHForkhead Transcription Factors/immunology-
dc.subject.MESHForkhead Transcription Factors/metabolism-
dc.subject.MESHHerpesvirus 1, Human/pathogenicity-
dc.subject.MESHInterferon-gamma/blood-
dc.subject.MESHInterleukin-10/blood-
dc.subject.MESHInterleukin-17/blood-
dc.subject.MESHInterleukin-2 Receptor alpha Subunit/immunology*-
dc.subject.MESHInterleukin-6/blood-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHSpleen/cytology-
dc.subject.MESHSpleen/immunology-
dc.subject.MESHT-Lymphocytes, Regulatory/immunology*-
dc.subject.MESHTransforming Growth Factor beta/blood-
dc.subject.MESHTumor Necrosis Factor-alpha/blood-
dc.subject.MESHUp-Regulation-
dc.titleCD4(+) CD25(+) regulatory T cells ameliorate Behcet's disease-like symptoms in a mouse model-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학)-
dc.contributor.googleauthorJua Shim-
dc.contributor.googleauthorEun-So Lee-
dc.contributor.googleauthorSun Park-
dc.contributor.googleauthorDongsik Bang-
dc.contributor.googleauthorSeonghyang Sohn-
dc.identifier.doi10.3109/14653249.2011.571245-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01784-
dc.relation.journalcodeJ00694-
dc.identifier.eissn1477-2566-
dc.identifier.pmid21506890-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1465324911705643-
dc.subject.keywordBehcet's disease-
dc.subject.keywordherpes simplex virus-
dc.subject.keywordmouse model-
dc.subject.keywordregulatory T cells-
dc.subject.keywordsystemic inflammation-
dc.contributor.alternativeNameBang, Dong Sik-
dc.contributor.affiliatedAuthorBang, Dong Sik-
dc.rights.accessRightsnot free-
dc.citation.volume13-
dc.citation.number7-
dc.citation.startPage835-
dc.citation.endPage847-
dc.identifier.bibliographicCitationCYTOTHERAPY, Vol.13(7) : 835-847, 2011-
dc.identifier.rimsid28101-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

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