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The association between coronary artery calcification and mean platelet volume in the general population

Authors
 Dong Hyuk Jung ; Hye Ree Lee ; Jae Yong Shim ; Byung Jin Park ; Jong Koo Kim ; Yong Jae Lee 
Citation
 Platelets, Vol.22(8) : 567~571, 2011 
Journal Title
 Platelets 
ISSN
 0953-7104 
Issue Date
2011
Abstract
Patients with coronary artery calcification have an increased risk of coronary vascular events and mortality. Coronary artery calcification can be quantified using the coronary calcium score (CCS) from multi-detected row computed tomography (MDCT), and the score is proportionally related to the severity of atherosclerotic disease. Mean platelet volume (MPV) is gaining interest as a new independent cardiovascular risk factor. Accordingly, the aim of our study was to evaluate the relationship between CCS and MPV in the general population. A total of 2116 individuals were enrolled from a health promotion center between July 2007 and June 2010. Among them, 259 subjects were included in the final analysis. MDCT was used to measure CCS and CCS > 1 was defined as the presence of coronary calcification. The MPV value was significantly higher in the coronary artery calcification group than in the control group. Multivariate analyses showed that MPV was positively associated with coronary calcification (OR, 1.61; 95% CI 1.02-2.55). In summary, there was a significant association between coronary artery calcification and MPV in the general population. Therefore, the detection of elevated MPV should alert clinicians to the coexistence of multiple underlying CVD risk factors warranting early evaluation and treatment.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/95075
DOI
abs/10.3109/09537104.2011.580397
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Family Medicine
Yonsei Authors
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Link
 http://informahealthcare.com/doi/abs/10.3109/09537104.2011.580397
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