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글루타메이트 수용체(GRIN2B) 유전자와 강박장애 발병 연령과의 관련성
DC Field | Value | Language |
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dc.contributor.author | 김찬형 | - |
dc.contributor.author | 노대영 | - |
dc.date.accessioned | 2014-12-20T17:40:53Z | - |
dc.date.available | 2014-12-20T17:40:53Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1738-9046 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95060 | - |
dc.description.abstract | Objectives : An early age at onset of obsessive compulsive symptoms in family studies has been strongly associated with a more familial form of obsessive compulsive disorder (OCD). Further, many reports have suggested that early- and late- onset OCD represent separate subtypes of the disorder. The aim of this study was to investigate the associations between the glutamate receptor, the ionotropic, n-methyl-d-aspartate (NMDA) subunit 2B gene (GRIN2B) polymorphisms, and onset of OCD in the Korean population. Methods : We recruited 109 OCD patients and classified them into early- (age of onset <18 years) and late-onset groups (age of onset18). Genomic DNA was extracted from their blood after which the genotypes and allelic frequencies of the two GRIN2B polymorphisms (5072T/G and 5988T/C) were compared in the two groups. We also compared genetic data between child- (age of onset15) and adult-onset groups (age of onset19) using the same protocol. Results : There were no significant differences between the early- and late-onset groups with respect to genotype. Moreover, we could not find any differences in genotype frequencies between child and adult-onset groups. Conclusions : Our study suggested that GRIN2B polymorphisms (5072T/G and 5988T/C) do not affect the onset of OCD in Koreans. However, this finding has resulted from a preliminary study and thus, further study is required. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 34~39 | - |
dc.relation.isPartOf | Anxiety and Mood (대한불안의학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 글루타메이트 수용체(GRIN2B) 유전자와 강박장애 발병 연령과의 관련성 | - |
dc.title.alternative | Association between the GRIN2B Gene and Age of Onset in Obsessive-Compulsive Disorder | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학) | - |
dc.contributor.googleauthor | 황성식 | - |
dc.contributor.googleauthor | 노대영 | - |
dc.contributor.googleauthor | 김찬형 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01036 | - |
dc.contributor.localId | A01276 | - |
dc.relation.journalcode | J03056 | - |
dc.subject.keyword | Obsessive-compulsive disorder | - |
dc.subject.keyword | GRIN2B gene | - |
dc.subject.keyword | Age of onset. | - |
dc.contributor.alternativeName | Kim, Chan Hyung | - |
dc.contributor.alternativeName | Roh, Dae Young | - |
dc.contributor.affiliatedAuthor | Kim, Chan Hyung | - |
dc.contributor.affiliatedAuthor | Roh, Dae Young | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 7 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 34 | - |
dc.citation.endPage | 39 | - |
dc.identifier.bibliographicCitation | Anxiety and Mood (대한불안의학회지), Vol.7(1) : 34-39, 2011 | - |
dc.identifier.rimsid | 27016 | - |
dc.type.rims | ART | - |
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