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A triazine compound S06 inhibits proinvasive crosstalk between carcinoma cells and stromal fibroblasts via binding to heat shock protein 90.

DC Field Value Language
dc.contributor.author김진-
dc.date.accessioned2014-12-20T17:36:49Z-
dc.date.available2014-12-20T17:36:49Z-
dc.date.issued2011-
dc.identifier.issn1074-5521-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/94933-
dc.description.abstractCarcinoma-associated fibroblasts (CAFs) promote tumor invasion by secreting soluble factors. A tagged triazine library was screened in our novel transwell coculture model of CAF and oral squamous cell carcinoma (OSCC). We discovered compound S06, which reduced OSCC invasion by inhibiting secretion of CAF-derived proinvasive chemokines. The N-terminus of Hsp90 was found to be the cellular target of S06. Importantly, S06 did not induce hepatic toxicity, a side effect associated with well-known Hsp90 inhibitors. Moreover, S06 inhibited tumor cell migration in a zebrafish xenograft model. Our results demonstrate that Hsp90 is a novel target for stromal-based therapy to modulate proinvasive molecular crosstalk within the tumor microenvironment. Furthermore, S06 represents a new class of Hsp90 inhibitor and is an attractive candidate for anticancer drug development.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1581~1590-
dc.relation.isPartOfCHEMISTRY & BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAntineoplastic Agents/pharmacology-
dc.subject.MESHCarcinoma, Squamous Cell/metabolism-
dc.subject.MESHCarcinoma, Squamous Cell/pathology-
dc.subject.MESHCell Communication/drug effects*-
dc.subject.MESHCell Line-
dc.subject.MESHCell Movement-
dc.subject.MESHChemokines/metabolism-
dc.subject.MESHFibroblasts/metabolism-
dc.subject.MESHHSP90 Heat-Shock Proteins/antagonists & inhibitors-
dc.subject.MESHHSP90 Heat-Shock Proteins/genetics-
dc.subject.MESHHSP90 Heat-Shock Proteins/metabolism*-
dc.subject.MESHHumans-
dc.subject.MESHMouth Neoplasms/metabolism-
dc.subject.MESHMouth Neoplasms/pathology-
dc.subject.MESHProtein Binding-
dc.subject.MESHRNA Interference-
dc.subject.MESHRNA, Small Interfering/metabolism-
dc.subject.MESHTransplantation, Heterologous-
dc.subject.MESHTriazines/chemistry-
dc.subject.MESHTriazines/pharmacology*-
dc.subject.MESHZebrafish-
dc.titleA triazine compound S06 inhibits proinvasive crosstalk between carcinoma cells and stromal fibroblasts via binding to heat shock protein 90.-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Pathology (구강병리학)-
dc.contributor.googleauthorDa-Woon Jung-
dc.contributor.googleauthorJinmi Kim-
dc.contributor.googleauthorZhong Min Che-
dc.contributor.googleauthorEun-Sang Oh-
dc.contributor.googleauthorGicheon Kim-
dc.contributor.googleauthorSoo Hyun Eom-
dc.contributor.googleauthorSin-Hyeog Im-
dc.contributor.googleauthorHyung-Ho Ha-
dc.contributor.googleauthorYoung-Tae Chang-
dc.contributor.googleauthorDarren R. Williams-
dc.contributor.googleauthorJin Kim-
dc.identifier.doi10.1016/j.chembiol.2011.10.001-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01009-
dc.relation.journalcodeJ00515-
dc.identifier.eissn1879-1301-
dc.identifier.pmid22195560-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1074552111003607-
dc.contributor.alternativeNameKim, Jin-
dc.contributor.affiliatedAuthorKim, Jin-
dc.rights.accessRightsnot free-
dc.citation.volume18-
dc.citation.number12-
dc.citation.startPage1581-
dc.citation.endPage1590-
dc.identifier.bibliographicCitationCHEMISTRY & BIOLOGY , Vol.18(12) : 1581-1590, 2011-
dc.identifier.rimsid26927-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers

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