Biochemical characterization of the TEM-107 extended-spectrum β-lactamase in a Klebsiella pneumoniae isolate from South Korea.

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Authors: Kyungwon Lee ; Jong Hwa Yum ; Dongeun Yong ; Seok Hoon Jeong ; Gian Maria Rossolini ; Jean-Denis Docquier ; Yunsop Chong

Citation: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Vol.55(12) : 5930-5932, 2011

MeSH: Adolescent ; Amino Acid Substitution* ; Anti-Bacterial Agents/pharmacology* ; Cefotaxime/pharmacology ; Ceftazidime/pharmacology ; Clavulanic Acid/pharmacology ; Conjugation, Genetic ; Escherichia coli/enzymology ; Escherichia coli/genetics ; Female ; Humans ; Kinetics ; Klebsiella Infections/microbiology* ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/enzymology* ; Klebsiella pneumoniae/isolation & purification* ; Microbial Sensitivity Tests/standards ; Republic of Korea ; beta-Lactam Resistance/genetics ; beta-Lactamases/chemistry ; beta-Lactamases/genetics* ; beta-Lactamases/metabolism

Abstract: The TEM-107 extended-spectrum β-lactamase detected in a Klebsiella pneumoniae clinical isolate had a Gly238Ser substitution compared to the TEM-43 β-lactamase. The MIC of ceftazidime was higher (64 μg/ml) than that of cefotaxime (2 μg/ml) for the isolate. Clavulanic acid reduced the MIC of ceftazidime 64-fold.