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조기 난소 부전의 임상 양상에 관한 연구

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dc.contributor.author서석교-
dc.contributor.author이병석-
dc.date.accessioned2014-12-20T17:35:37Z-
dc.date.available2014-12-20T17:35:37Z-
dc.date.issued2011-
dc.identifier.issn1226-8704-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/94894-
dc.description.abstractObjectives: Premature ovarian failure (POF) is a syndrome defined as the cessation of ovarian function before the age of 40 years that is characterized by amenorrhoea associated with elevated gonadotropin levels. The aim of this study was to compare clinical manifestation of primary amenorrhea and secondary amenorrhea group. Methods: This study was designed as a retrospective multicenter study of 262 women with premature ovarian failure. Sixty eight women with primary amenorrhea and 194 women with secondary amenorrhea were evaluated and hormonal level, lipid profile, bone mineral density, and pregnancy rates were compared. Results: The estradiol level was markedly lower in primary amenorrhea than secondary amenorrhea. The pregnancy rate of 43.3% before the diagnosis in secondary amenorrhea was markedly higher than the rate of 0% in primary amenorrhea. The pregnancy rates after treatment was 5.9% in primary amenorrhea, but 1.0% after diagnosis and 2.8% after treatment in secondary amenorrhea. The pregnancy rate after hormonal treatment was 3.7% in total, 8.3% in primary amenorrhea, and 2.8% in secondary amenorrhea. In nine cases of pregnancy, seven cases were after estrogen-progestin (EP), one case was after clomiphene citrate and one case was after EP/human menopausal gonodotropin (hMG). And In nine cases of pregnancy, six cases resulted from oocyte donation. The prevalence of osteopenia/osteoporosis was markedly higher in primary amenorrhea than in secondary amenorrhea. Conclusion: Premature ovarian failure has negative influences on the physical and psychological health of young patients. Effective management should include earlier diagnosis and intensive medical intervention to relieve symptoms of estrogen deficiency and to treat long-term disease such as osteoporosis and in assisted pregnancy by oocyte donation.-
dc.description.statementOfResponsibilityopen-
dc.format.extent160~165-
dc.relation.isPartOfJournal of Korean Society of Menopause (대한폐경학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title조기 난소 부전의 임상 양상에 관한 연구-
dc.title.alternativeRetrospective Multicenter Study on Clinical Aspects in Premature Ovarian Failure-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics & Gynecology (산부인과학)-
dc.contributor.googleauthor허지수-
dc.contributor.googleauthor서석교-
dc.contributor.googleauthor김미란-
dc.contributor.googleauthor정혜원-
dc.contributor.googleauthor윤병구-
dc.contributor.googleauthor이병석-
dc.contributor.googleauthor강병문-
dc.contributor.googleauthor최 훈-
dc.contributor.googleauthor박형무-
dc.contributor.googleauthor김정구-
dc.contributor.googleauthor폐경연구소위원회-
dc.identifier.doi10.6118/jksm.2011.17.3.160-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01888-
dc.contributor.localIdA02795-
dc.relation.journalcodeJ01546-
dc.subject.keywordPremature ovarian failure-
dc.subject.keywordPrimary amenorrhea-
dc.subject.keywordSecondary amenorrhea-
dc.contributor.alternativeNameSeo, Seok Kyo-
dc.contributor.alternativeNameLee, Byung Seok-
dc.contributor.affiliatedAuthorSeo, Seok Kyo-
dc.contributor.affiliatedAuthorLee, Byung Seok-
dc.rights.accessRightsfree-
dc.citation.volume17-
dc.citation.number3-
dc.citation.startPage160-
dc.citation.endPage165-
dc.identifier.bibliographicCitationJournal of Korean Society of Menopause (대한폐경학회지), Vol.17(3) : 160-165, 2011-
dc.identifier.rimsid27832-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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