지난 50년간 국내 항생제 내성의 변화와 향후 전망 - 그람음성 세균

Abstract

The increasing prevalence of antimicrobial-resistant bacteria has become a serious problem in many parts of the world, including Korea. The resistance of of Grampositive cocci was once considered to be a more serious problem, but the recent emergence of multi-resistant Gram-negative bacilli has raised great concerns. In Korea, the prevalence of ESBL-producing Escherichia coli and Klebsiella pneumoniae and fluoroquinolone-resistant E. coli , K. pneumoniae, Acinetobacter spp., and Pseudomonas aeruginosa has gradually increased. The increase in imipenem resistance was slight in P. aeruginosa , but drastic in Acinetobacter spp. It is certain that problematic antimicrobial-organism combinations are prevalent in Korea, increase of resistant bacteria will continue in the future. The development of new antimicrobial agents is considered difficult. Therefore, it is very important to use existing antimicrobial agents prudently, to extend the efficacy, to prevent infections, and tostrengthen infection control measures to prevent spread of resistant bacteria