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An Immune-compromised Method for Tooth Transplantation Using Adult Bone Marrow Stromal Cells and Embryonic Tooth Germ

 Hyuk-Jae Kwon  ;  Gi-Hee Park  ;  Sung-Won Cho  ;  Han-Sung Jung  ;  Min-Jung Lee  ;  Eun-Jung Kim 
 Korean Journal of Physical Anthropology (대한체질인류학회지), Vol.24(4) : 217-224, 2011 
Journal Title
 Korean Journal of Physical Anthropology  (대한체질인류학회지) 
Issue Date
Tooth transplantation using autogenic adult teeth or embryonic tooth germs is the one of best treatments for replacement of missing teeth, but there are limitations in the accessibility. Isogenic or xenogenic tooth transplantation has been failed because of the immune rejection response occurring in the periodontal ligament of transplanted tooth. In this study, by utilizing the recombination between mouse embryonic tooth germ and mouse adult bone marrow stromal cells, we tried to replace the periodontal tissues such as periodontal ligament and alveolar bone with adult bone marrow stromal cells. At four weeks after the transplantation of the recombinant into a kidney, adult bone marrow-derived cells cells were observed in the periodontal ligament and alveolar bone. This result indicates that adult bone marrow stromal cells can participate in the formation of periodontal tissues. If these tooth and periodontal tissues are transplanted into host who donates adult bone marrow stromal cells, adult bone marrow-derived cells will be regarded as host cells, and immune rejection response will not occur in these cells. Therefore, it is suggested that recombination between adult bone marrow stromal cells and embryonic tooth germ is a good candidate method using xenogenic tooth germ for replacement of missing teeth in human by replacing cells in periodontal tissues with human adult bone marrow stromal cells.
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실)
Yonsei Authors
권혁제(Kwon, Hyuk Jae) ; 김은정(Kim, Eun Jung) ; 박지희(Park, Gi Hee) ; 이민정(Lee, Min Jung) ; 정한성(Jung, Han Sung) ; 조성원(Cho, Sung Won)
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